短梗霉属海洋来源真菌中具有抗结核活性的短梗霉胺类化合物。
Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor.
机构信息
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Org Lett. 2012 Sep 21;14(18):4770-3. doi: 10.1021/ol302051x. Epub 2012 Sep 10.
An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.
从中国渤海采集的沉积物中分离到的变色曲霉产生了新的二聚二酮哌嗪布列维酰胺 S（1），以及三个新的单体代谢产物，布列维酰胺 T（2）、U（3）和 V（4）。结构通过详细的光谱分析确定。布列维酰胺 S 对卡介苗（BCG）表现出选择性的抗菌活性，提示了一种新的作用机制，可能为开发下一代抗结核药物提供信息。
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