洛美维定菌素 C-E 的分离、洛美维定菌素 C 向洛美维定菌素 A 的转化、洛美维定菌素 A 的全结构解析及构效关系分析。
Isolation of lomaiviticins C-E, transformation of lomaiviticin C to lomaiviticin A, complete structure elucidation of lomaiviticin A, and structure-activity analyses.
机构信息
Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.
出版信息
J Am Chem Soc. 2012 Sep 19;134(37):15285-8. doi: 10.1021/ja3074984. Epub 2012 Sep 10.
PMID:22963534
Abstract
We describe the isolation of (-)-lomaiviticins C-E (6-8), elucidation of the complete absolute and relative stereochemistry of (-)-lomaiviticin A (1), the synthetic conversion of (-)-lomaiviticin C (6) to (-)-lomaiviticin A (1), and the first evidence that the dimeric diazofluorene of (-)-lomaiviticin A (1) plays a defining and critical role in antiproliferative activity.
摘要
我们描述了 (-)-洛马维丁菌素 C-E（6-8）的分离，阐明了 (-)-洛马维丁菌素 A（1）的完整绝对和相对立体化学，(-)-洛马维丁菌素 C（6）向 (-)-洛马维丁菌素 A（1）的合成转化，以及首次证明 (-)-洛马维丁菌素 A（1）的二聚二氮杂芴在抗增殖活性中起着决定性和关键作用。
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