Mind, Brain Imaging and Neuroethics Research Unit, University of Ottawa Institute of Mental Health Research, Ottawa, Ont.
J Psychiatry Neurosci. 2013 Mar;38(2):84-96. doi: 10.1503/jpn.120059.
Studies of intrinsic brain activity in the resting state have become increasingly common. A productive discussion of what analysis methods are appropriate, of the importance of physiologic correction and of the potential interpretations of results has been ongoing. However, less attention has been paid to factors other than physiologic noise that may confound resting-state experiments. These range from straightforward factors, such as ensuring that participants are all instructed in the same manner, to more obscure participant-related factors, such as body weight. We provide an overview of such potentially confounding factors, along with some suggested approaches for minimizing their impact. A particular theme that emerges from the overview is the range of systematic differences between types of study groups (e.g., between patients and controls) that may influence resting-state study results.
静息态脑内活动的研究已经越来越普遍。目前正在进行关于哪些分析方法是合适的、生理校正的重要性以及结果的潜在解释的富有成效的讨论。然而，对于可能使静息态实验复杂化的除生理噪声以外的因素关注较少。这些因素范围从确保所有参与者都以相同的方式接受指导等简单因素到更模糊的与参与者相关的因素，如体重。我们提供了这种潜在混杂因素的概述，并提出了一些建议的方法来最小化它们的影响。从概述中出现的一个特别主题是研究组类型（例如，患者与对照组之间）之间可能影响静息态研究结果的系统差异范围。
