Department of Chemistry of Natural Compounds, National Research Center, Dokki 12622, Cairo, Egypt.
Nat Prod Res. 2013;27(14):1250-4. doi: 10.1080/14786419.2012.724417. Epub 2012 Sep 12.
Chemical investigation of the chloroform extract of the Egyptian Red Sea soft coral, Heteroxenia ghardaqensis (Family Xeniidae), led to the isolation of three gorgostane derivatives, namely gorgosten-5(E)-3β-ol (1), gorgostan-3β,5α,6β, 11α-tetraol (sarcoaldosterol A) (2) and gorgostan-3β,5α,6β-triol-11α-acetate (3). To our knowledge, sterol 3 is reported in this article for the first time. The structure elucidation of these compounds was deduced by 1-D and 2-D NMR as well as ESIMS. Sterol 1 showed moderate activity as growth inhibitor of human colon tumour cell lines.
对产自埃及红海的软珊瑚 Heteroxenia ghardaqensis（Xeniidae 科）的氯仿提取物进行化学研究，分离得到三种甾醇衍生物，分别为：戈尔戈甾-5(E)-3β-醇（1）、戈尔戈甾烷-3β,5α,6β,11α-四醇（sarcoaldosterol A）（2）和戈尔戈甾烷-3β,5α,6β-三醇-11α-乙酸酯（3）。据我们所知，本文首次报道了化合物 3 的甾醇结构。这些化合物的结构通过 1-D 和 2-D NMR 以及 ESIMS 推导得出。化合物 1 对人结肠肿瘤细胞系的生长具有中等抑制活性。
