Hermans Kevin Cm, Daskalopoulos Evangelos P, Blankesteijn W Matthijs
Department of Pharmacology, Cardiovascular Research Institute Maastricht, Maastricht University, 50 Universiteitssingel, 6229ER Maastricht, PO Box 616 6200MD, Maastricht, The Netherlands.
Fibrogenesis Tissue Repair. 2012 Sep 11;5(1):16. doi: 10.1186/1755-1536-5-16.
Following myocardial infarction, wound healing takes place in the infarct area where the non-viable cardiac tissue is replaced by a scar. Inadequate wound healing or insufficient maintenance of the extracellular matrix in the scar can lead to excessive dilatation of the ventricles, one of the hallmarks of congestive heart failure. Therefore, it is important to better understand the wound-healing process in the heart and to develop new therapeutic agents that target the infarct area in order to maintain an adequate cardiac function. One of these potential novel therapeutic targets is Wnt signaling. Wnt signaling plays an important role in embryonic myocardial development but in the adult heart the pathway is thought to be silent. However, there is increasing evidence that components of the Wnt pathway are re-expressed during cardiac repair, implying a regulatory role. Recently, several studies have been published where the effect of interventions in Wnt signaling on infarct healing has been studied. In this review, we will summarize the results of these studies and discuss the effects of these interventions on the different cell types that are involved in the wound healing process.
心肌梗死后，梗死区域会发生伤口愈合，其中无活力的心脏组织会被瘢痕组织取代。伤口愈合不充分或瘢痕中细胞外基质维持不足会导致心室过度扩张，这是充血性心力衰竭的特征之一。因此，更好地了解心脏的伤口愈合过程并开发针对梗死区域的新型治疗药物以维持足够的心脏功能非常重要。这些潜在的新型治疗靶点之一是Wnt信号通路。Wnt信号通路在胚胎心肌发育中起重要作用，但在成体心脏中该通路被认为是沉默的。然而，越来越多的证据表明，Wnt通路的成分在心脏修复过程中会重新表达，这意味着其具有调节作用。最近，已经发表了几项研究，其中研究了Wnt信号通路干预对梗死愈合的影响。在本综述中，我们将总结这些研究的结果，并讨论这些干预对参与伤口愈合过程的不同细胞类型的影响。
