Department of Public Health, National Defence Medical Centre, Taipei, Taiwan, ROC.
J Expo Sci Environ Epidemiol. 2013 Jan-Feb;23(1):94-100. doi: 10.1038/jes.2012.87. Epub 2012 Sep 12.
Cooking oil fumes (COF) contain polycyclic aromatic hydrocarbons (PAHs), heterocyclic aromatic amines, benzene, and formaldehyde, which may cause oxidative damages to DNA and lipids. We assessed the relations between exposure to COF and subsequent oxidative DNA damage and lipid peroxidation among military cooks and office-based soldiers. The study population, including 61 Taiwanese male military cooks and a reference group of 37 office soldiers, collected urine samples pre-shift of the first weekday and post-shift of the fifth workday. We measured airborne particulate PAHs in military kitchens and offices and concentrations of urinary 1-OHP, a biomarker of PAH exposure, urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarkers of oxidative DNA damage, and urinary isoprostane (Isop). Airborne particulate PAHs levels in kitchens significantly exceeded those in office areas. The concentrations of urinary 1-OHP among military cooks increased significantly after 5 days of exposure to COF. Using generalized estimating equation analysis adjusting for confounding, a change in log(8-OHdG) and log(Isop) were statistically significantly related to a unit change in log(1-OHP) (regression coefficient (β), β=0.06, 95% CI 0.001-0.12) and (β=0.07, 95% CI 0.001-0.13), respectively. Exposure to PAHs, or other compounds in cooking oil fumes, may cause both oxidative DNA damage and lipid peroxidation.
食用油油烟（COF）含有多环芳烃（PAHs）、杂环芳香胺、苯和甲醛，可能导致 DNA 和脂质的氧化损伤。我们评估了军事厨师和办公室士兵暴露于 COF 与随后的氧化 DNA 损伤和脂质过氧化之间的关系。研究人群包括 61 名台湾男性军事厨师和 37 名办公室士兵的参考组，他们在第一个工作日的班前和第五个工作日的班后采集尿样。我们测量了军事厨房和办公室空气中的颗粒状 PAHs 以及尿液中 1-OHP 的浓度，1-OHP 是 PAH 暴露的生物标志物，尿液中 8-羟基脱氧鸟苷（8-OHdG），一种氧化 DNA 损伤的生物标志物，以及尿液中的异前列烷（Isop）。厨房空气中的颗粒状 PAHs 水平明显高于办公室区域。军事厨师在接触 COF 5 天后，尿液 1-OHP 浓度显著升高。使用广义估计方程分析调整混杂因素后，log(8-OHdG)和 log(Isop)的变化与 log(1-OHP)的单位变化呈统计学相关（回归系数 (β)，β=0.06，95%CI 0.001-0.12）和（β=0.07，95%CI 0.001-0.13）。接触多环芳烃或食用油油烟中的其他化合物可能会导致氧化 DNA 损伤和脂质过氧化。
