Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Immunol Res. 2013 Mar;55(1-3):75-82. doi: 10.1007/s12026-012-8350-2.
Neutrophil (PMN) recruitment from the blood stream into surrounding tissues involves a regulated series of events central to acute responses in host defense. Accumulation of PMN within mucosal tissues has historically been considered pathognomonic features of both acute and chronic inflammatory conditions. Historically, PMNs have been deemed necessary but detrimental when recruited, given the potential for tissue damage that results from a variety of mechanisms. Recent work, however, has altered our preconceived notions of PMN contributions to inflammatory processes. In particular, significant evidence implicates a central role for the PMN in triggering inflammatory resolution. Such mechanisms involve both metabolic and biochemical crosstalk pathways during the intimate interactions of PMN with other cell types at inflammatory sites. Here, we highlight several recent examples of how PMN coordinate the resolution of ongoing inflammation, with a particular focus on the gastrointestinal mucosa.
中性粒细胞（PMN）从血液中募集到周围组织中，涉及到一系列受调节的事件，这些事件是宿主防御中急性反应的核心。PMN 在黏膜组织中的积累在历史上一直被认为是急性和慢性炎症状态的特征。从历史上看，PMN 被认为是在招募时是必要的，但也是有害的，因为它可能会导致各种机制引起的组织损伤。然而，最近的研究改变了我们对 PMN 对炎症过程贡献的先入为主的观念。特别是，有大量证据表明 PMN 在引发炎症消退中起着核心作用。这种机制涉及到 PMN 与炎症部位的其他细胞类型之间的密切相互作用过程中的代谢和生化串扰途径。在这里，我们强调了 PMN 协调正在进行的炎症消退的几个最近的例子，特别关注胃肠道黏膜。
