Walter S D, Marrett L D, From L, Hertzman C, Shannon H S, Roy P
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Am J Epidemiol. 1990 Feb;131(2):232-43. doi: 10.1093/oxfordjournals.aje.a115493.
Data are presented from a large case-control study (583 cases, 608 controls) to estimate the association of melanoma with the use of sunbeds and sunlamps. Odds ratios of 1.88 and 1.45 were found for ever having used a sunbed or sunlamp in males and females, respectively, which was statistically significant in males and of borderline significance in females. These effects persisted when adjustments were made for age and a variety of potential confounders. The effect was slightly stronger for lentigo maligna and for lesions of the face, head, neck, and arms. The risk was greater and significant for both sexes for domestic use of sunbeds/sunlamps, and increased with duration and amount of use. A comparison of 43 cases interviewed before a diagnosis of melanoma had been made with the other 540 cases suggests that recall bias was not responsible for the association. The authors conclude that use of artificial tanning devices appears to be a risk factor for melanoma.
本文数据来自一项大型病例对照研究(583例病例,608例对照),旨在评估黑素瘤与使用日光浴床和太阳灯之间的关联。男性和女性曾使用日光浴床或太阳灯的优势比分别为1.88和1.45,在男性中具有统计学意义,在女性中具有临界意义。在对年龄和各种潜在混杂因素进行调整后,这些效应依然存在。对于恶性雀斑样痣以及面部、头部、颈部和手臂的病变,这种效应稍强。在家中使用日光浴床/太阳灯,男女的风险都更高且具有统计学意义,并且随着使用时间和使用量的增加而增加。对43例在黑素瘤诊断前接受访谈的病例与其他540例病例进行比较表明,回忆偏倚并非导致这种关联的原因。作者得出结论,使用人工晒黑设备似乎是黑素瘤的一个危险因素。