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苦参的抗肿瘤活性：文献综述。

Antitumor activities of kushen: literature review.

机构信息

Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai 201203, China.

出版信息

Evid Based Complement Alternat Med. 2012;2012:373219. doi: 10.1155/2012/373219. Epub 2012 Aug 28.

DOI:10.1155/2012/373219
PMID:22969826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3434675/
Abstract

To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and kushen flavonoids (KS-Fs) are well-characterized components in kushen. KS-As containing oxymatrine, matrine, and total alkaloids have been developed in China as anticancer drugs. More potent antitumor activities were identified in KS-Fs than in KS-As in vitro and in vivo. KS-Fs may be developed as novel antitumor agents.

摘要

发现和开发具有治疗选择性的新型天然化合物，或者能够优先杀死癌细胞而对正常细胞没有显著毒性，是癌症化疗的一个重要领域。苦参，是苦参的干燥根，在中国传统医学中用于治疗炎症性疾病和癌症已有悠久的历史。苦参生物碱（KS-As）和苦参黄酮（KS-Fs）是苦参中的两种特征成分。在中国，含有氧化苦参碱、苦参碱和总生物碱的苦参生物碱已被开发为抗癌药物。体外和体内研究表明，苦参黄酮的抗肿瘤活性比苦参生物碱更强。苦参黄酮可能被开发为新型抗肿瘤药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7e5/3434675/006c5731e405/ECAM2012-373219.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7e5/3434675/006c5731e405/ECAM2012-373219.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7e5/3434675/006c5731e405/ECAM2012-373219.001.jpg

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Endocr Metab Immune Disord Drug Targets. 2011 Sep 1;11(3):247-61. doi: 10.2174/187153011796429790.
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Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c.氧化苦参碱通过调节 Bcl-2 和 IAP 家族的表达以及细胞色素 c 的释放诱导人胰腺癌细胞 PANC-1 凋亡。
J Exp Clin Cancer Res. 2011 Jun 29;30(1):66. doi: 10.1186/1756-9966-30-66.
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苦参素治疗红皮病型银屑病患者的疗效与安全性
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