神经内分泌免疫系统的胎儿编程与代谢性疾病
Fetal programming of the neuroendocrine-immune system and metabolic disease.
作者信息
Fisher R E, Steele M, Karrow N A
机构信息
Department of Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, ON, Canada N1G 2W1.
出版信息
J Pregnancy. 2012;2012:792934. doi: 10.1155/2012/792934. Epub 2012 Aug 16.
Adverse uterine environments experienced during fetal development can alter the projected growth pattern of various organs and systems of the body, leaving the offspring at an increased risk of metabolic disease. The thrifty phenotype hypothesis has been demonstrated as an alteration to the growth trajectory to improve the survival and reproductive fitness of the individual. However, when the intrauterine environment does not match the extrauterine environment problems can arise. With the increase in metabolic diseases in both Westernized and developing countries, it is becoming apparent that there is an environmental disconnect with the extrauterine environment. Therefore, the focus of this paper will be to explore the effects of maternal malnutrition on the offspring's susceptibility to metabolic disorders such as obesity, cardiovascular disease, and diabetes with emphasis on programming of the neuroendocrine-immune system.
胎儿发育期间经历的不良子宫环境会改变身体各器官和系统的预期生长模式，使后代患代谢性疾病的风险增加。节俭表型假说已被证明是生长轨迹的一种改变，以提高个体的生存和生殖适应性。然而，当子宫内环境与子宫外环境不匹配时，就会出现问题。随着西方化国家和发展中国家代谢性疾病的增加，子宫外环境与环境之间的脱节越来越明显。因此，本文的重点将是探讨母体营养不良对后代易患肥胖、心血管疾病和糖尿病等代谢紊乱的影响，重点是神经内分泌免疫系统的编程。
Zotero 插件