Schackert G, Price J E, Zhang R D, Bucana C D, Itoh K, Fidler I J
Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030.
Am J Pathol. 1990 Jan;136(1):95-102.
Cells from eight different human melanomas and two murine melanomas were injected into the internal carotid artery of anesthetized nude mice. Although all were injected by the same route, particular melanomas produced lesions in different regions of the brain. Two melanoma cell lines isolated originally from brain metastases in patients produced metastases predominantly in the brain parenchyma. In contrast, melanoma cells from subcutaneous or lymph node metastases produced more lesions in the meninges, choroid plexus, and ventricles than in the brain parenchyma. All of the melanomas grew in the brain after a direct intracerebral injection. The pattern of brain metastasis did not correlate with tumorigenicity per se or with the ability of the melanomas to grow in the lungs of nude mice. Two mouse melanomas showed different patterns of experimental metastasis after internal carotid artery injection, with one growing predominantly in the parenchyma and the other more frequently in the meninges and choroid plexus. The growth pattern of human melanoma metastasis in the brain of T cell-deficient nude mice suggests that it is determined by properties unique to each tumor interacting with the host's organ microenvironment.
将来自8种不同人类黑色素瘤和2种鼠类黑色素瘤的细胞注射到麻醉的裸鼠的颈内动脉中。尽管所有细胞都是通过相同途径注射的，但特定的黑色素瘤在大脑的不同区域产生病变。最初从患者脑转移灶分离出的两种黑色素瘤细胞系主要在脑实质中产生转移灶。相比之下，来自皮下或淋巴结转移灶的黑色素瘤细胞在脑膜、脉络丛和脑室中产生的病变比在脑实质中更多。所有黑色素瘤在直接脑内注射后都在脑中生长。脑转移模式与肿瘤本身的致瘤性或黑色素瘤在裸鼠肺部生长的能力无关。两种鼠类黑色素瘤在颈内动脉注射后显示出不同的实验转移模式，一种主要在实质中生长，另一种更频繁地在脑膜和脉络丛中生长。T细胞缺陷的裸鼠脑中人类黑色素瘤转移的生长模式表明，它是由每个肿瘤独特的特性与宿主器官微环境相互作用决定的。
