Photobiology Unit, Ninewells Hospital and Medical School, Dundee, UK.
Photodermatol Photoimmunol Photomed. 2012 Oct;28(5):235-9. doi: 10.1111/j.1600-0781.2012.00681.x.
BACKGROUND/PURPOSE: Conventional photodynamic therapy (PDT) can be inconvenient and uncomfortable. We studied low irradiance PDT using an ambulatory inorganic light-emitting diode.
Fifty-three patients with 61 lesions [superficial basal cell carcinoma (n = 30), Bowen's disease (n = 30), and actinic keratosis (AK; n = 1)] were studied. Two treatments of ambulatory PDT were undertaken 1 week apart (one treatment for AK). Clinical response was determined at 3 months, and the treatment cycle was repeated if there was residual disease. The endpoints assessed were pain during treatment (numerical rating scale (NRS); 0-10) and outcome at 1 year. Twenty-three of these patients also received conventional PDT to separate lesions.
The median NRS pain scores during first and second treatment were 2 (range 0-9) and 4 (0-9), respectively. Lesion clearance rate at 1 year after ambulatory PDT was 84% (21/25 lesions in 22 patients). Of the twenty-three patients treated with both ambulatory and conventional PDT, the median NRS was 1 (0-7) and 5 (1.5-9), respectively, with most patients preferring ambulatory PDT.
Ambulatory PDT is effective for superficial non-melanoma skin cancer, with 1 year clearance rates comparative to conventional PDT. Low irradiance ambulatory PDT may be less painful and more convenient than conventional PDT.
背景/目的：传统的光动力疗法（PDT）可能会带来不便和不适。我们研究了使用便携式无机发光二极管进行低辐照度 PDT。
53 名患者的 61 个病变[浅表基底细胞癌（n=30）、鲍文病（n=30）和光化性角化病（AK；n=1）]接受了研究。每周进行两次便携式 PDT 治疗（AK 进行一次治疗）。在 3 个月时评估临床反应，如果有残留疾病，则重复治疗周期。评估的终点包括治疗期间的疼痛（数字评分量表（NRS）；0-10）和 1 年后的结果。其中 23 名患者还接受了常规 PDT 以分离病变。
第一次和第二次治疗期间的中位数 NRS 疼痛评分分别为 2（范围 0-9）和 4（0-9）。在接受便携式 PDT 治疗 1 年后，病变清除率为 84%（22 名患者中的 25 个病变中的 21 个）。在接受便携式和常规 PDT 治疗的 23 名患者中，中位数 NRS 分别为 1（0-7）和 5（1.5-9），大多数患者更喜欢便携式 PDT。
便携式 PDT 对浅表非黑素瘤皮肤癌有效，1 年清除率与常规 PDT 相当。低辐照度的便携式 PDT 可能比常规 PDT 更舒适，且疼痛程度更低。
