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哺乳动物神经发生中 Notch 信号的遗传可视化。

Genetic visualization of notch signaling in mammalian neurogenesis.

机构信息

Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto, 606-8507, Japan.

出版信息

Cell Mol Life Sci. 2013 Jun;70(12):2045-57. doi: 10.1007/s00018-012-1151-x. Epub 2012 Sep 13.

DOI:10.1007/s00018-012-1151-x
PMID:22971775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3663255/
Abstract

Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling more precisely, it is important to reveal when, where, and how notch signaling is dynamically communicated between cells, for which the visualization of notch signaling is essential. In this review, we introduce recent technical advances in the visualization of notch signaling during neural development and in the adult brain, and we discuss the physiological significance of dynamic regulation of notch signaling.

摘要

Notch 信号通路在胚胎期和成年期大脑中神经干细胞的命运决定和分化中发挥着关键作用。现在很清楚的是， Notch 途径受到的调控比以前认为的要复杂和动态。为了更精确地了解 Notch 信号转导的功能细节，揭示 Notch 信号在细胞之间的动态传递的时间、地点和方式非常重要，这就需要 Notch 信号的可视化。在这篇综述中，我们介绍了在神经发育和成年大脑中 Notch 信号可视化的最新技术进展，并讨论了 Notch 信号动态调控的生理意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/14ea06596cc6/18_2012_1151_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/4ee40e0d7289/18_2012_1151_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/2f9988d45e15/18_2012_1151_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/4e33f8a4c667/18_2012_1151_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/14ea06596cc6/18_2012_1151_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/4ee40e0d7289/18_2012_1151_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/2f9988d45e15/18_2012_1151_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/4e33f8a4c667/18_2012_1151_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3424/11114031/14ea06596cc6/18_2012_1151_Fig4_HTML.jpg

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