Gu Wen, Qiao Chao
College of Chemical Engineering, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, P R China.
Chem Pharm Bull (Tokyo). 2012;60(11):1474-7. doi: 10.1248/cpb.c12-00643. Epub 2012 Aug 27.
Two new furandiones named asperterone B (1) and C (2) together with four known metabolites (3-6) were isolated from the liquid culture of the endophytic fungus Aspergillus terreus MHL-P22 residing in the fresh leaves of Malus halliana. The structures of the new compounds were elucidated by analysis of their MS, IR, 1D- and 2D-NMR spectra. 1 and 2 showed moderate cytotoxic activities against human colorectal carcinoma SW1116 cells with IC(50) values of 57.5 and 71.0 µM, respectively. The biosynthetic pathway for 1, 2 and their analogues was also postulated and briefly discussed.
从苹果属植物新鲜叶片中内生真菌土曲霉MHL - P22的液体培养物中分离出两种新的呋喃二酮，分别命名为asperterone B（1）和C（2），以及四种已知的代谢产物（3 - 6）。通过对它们的质谱、红外光谱、一维和二维核磁共振光谱分析，阐明了新化合物的结构。化合物1和2对人结肠癌细胞SW1116显示出中等细胞毒性活性，IC(50)值分别为57.5和71.0 μM。还推测并简要讨论了化合物1、2及其类似物的生物合成途径。
