来自海洋来源真菌青霉属sp. ghq208的罕见吡咯基4-喹啉酮生物碱。
Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. ghq208.
作者信息
Gao Huquan, Zhang Lianqing, Zhu Tianjiao, Gu Qianqun, Li Dehai
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P R China.
出版信息
Chem Pharm Bull (Tokyo). 2012;60(11):1458-60. doi: 10.1248/cpb.c12-00487. Epub 2012 Sep 4.
One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. ghq208. The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds (2, 3) exhibited moderate cytotoxicities against the HepG2 cell line with IC(50) values of 11.3 and 13.2 µM, respectively.
从海洋来源的青霉菌株ghq208中分离出一种新的吡咯基4-喹啉酮生物碱，青霉素啉E（1），以及三种已知衍生物，甲基青霉素啉（2）、青霉素啉（3）和喹诺内酯（4）。通过光谱方法阐明了这些分离化合物的结构。化合物（2,3）对HepG2细胞系表现出中等细胞毒性，IC50值分别为11.3和13.2 μM。
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