Key Laboratory of Marine Drugs, Chinese Ministry of Education School of Medicine and Pharmacy, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, PR China.
J Antibiot (Tokyo). 2010 Apr;63(4):165-70. doi: 10.1038/ja.2010.11. Epub 2010 Feb 26.
Four new alkaloids, including two new meleagrin analogs, meleagrin D (1) and E (2), and two new diketopiperazines, roquefortine H (3) and I (4), were isolated from a deep ocean sediment-derived fungus Penicillium sp. Meleagrin D (1) and E (2) possess unprecedented acetate-mevalonate-derived side chains on the imidazole moiety. These new meleagrins showed weak cytotoxicity against the A-549 cell line, whereas meleagrin B (5) and meleagrin (6), which were isolated previously from the same strain, induced HL-60 cell apoptosis or arrested the cell cycle through G(2)/M phase, respectively. The results indicate that the distinct substitutions on the imidazole ring significantly influence the cytotoxicity of the meleagrin alkaloids.
从深海沉积物来源的真菌青霉（Penicillium）中分离得到四个新的生物碱，包括两个新的麦角灵类似物，麦角灵 D（1）和 E（2），以及两个新的二酮哌嗪，罗奎福汀 H（3）和 I（4）。麦角灵 D（1）和 E（2）在咪唑部分具有前所未有的醋酸甲羟戊酸衍生侧链。这些新的麦角灵对 A-549 细胞系表现出较弱的细胞毒性，而先前从同一菌株中分离得到的麦角灵 B（5）和麦角灵（6）则分别通过诱导 HL-60 细胞凋亡或使细胞周期停滞在 G2/M 期来发挥作用。结果表明，咪唑环上的不同取代基显著影响麦角灵生物碱的细胞毒性。
