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Production of KPC-2 alone does not always result in β-lactam MICs representing resistance in gram-negative pathogens.

作者信息

Roth Amanda L, Thomson Kenneth S, Lister Philip D, Hanson Nancy D

机构信息

Department of Medical Microbiology and Immunology Creighton University Omaha, Nebraska, USA.

出版信息

J Clin Microbiol. 2012 Dec;50(12):4183-4. doi: 10.1128/JCM.02194-12. Epub 2012 Sep 12.

DOI:10.1128/JCM.02194-12
PMID:22972823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3502953/
Abstract
摘要

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Production of KPC-2 alone does not always result in β-lactam MICs representing resistance in gram-negative pathogens.单独产生KPC-2并不总是导致革兰氏阴性病原体中代表耐药性的β-内酰胺最低抑菌浓度（MIC）。
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Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases.OP0595与β-内酰胺类药物联合对产超广谱β-内酰胺酶、AmpC酶和碳青霉烯水解β-内酰胺酶的革兰氏阴性菌的活性。
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β-lactam susceptibility in extended-spectrum β-lactamase-producing isolates.产超广谱β-内酰胺酶菌株对β-内酰胺类药物的敏感性
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Evaluation of a DNA microarray, the check-points ESBL/KPC array, for rapid detection of TEM, SHV, and CTX-M extended-spectrum beta-lactamases and KPC carbapenemases.评价一种 DNA 微阵列检测试剂盒，即耐药基因检测微阵列（check-points ESBL/KPC array），用于快速检测 TEM、SHV 和 CTX-M 型超广谱β-内酰胺酶以及 KPC 碳青霉烯酶。
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Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae testing susceptible to cefepime by reference methods.产碳青霉烯酶肠杆菌科细菌对头孢吡肟敏感的检测——参考方法。
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本文引用的文献

1
Are susceptibility tests enough, or should laboratories still seek ESBLs and carbapenemases directly?药敏试验就足够了吗，还是实验室仍应直接检测超广谱β-内酰胺酶（ESBLs）和碳青霉烯酶？
J Antimicrob Chemother. 2012 Jul;67(7):1569-77. doi: 10.1093/jac/dks088. Epub 2012 Mar 29.
2
bla(KPC) RNA expression correlates with two transcriptional start sites but not always with gene copy number in four genera of Gram-negative pathogens.bla(KPC) RNA 表达与两个转录起始位点相关，但并不总是与四种革兰氏阴性病原体的基因拷贝数相关。
Antimicrob Agents Chemother. 2011 Aug;55(8):3936-8. doi: 10.1128/AAC.01509-10. Epub 2011 May 16.
3
Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae.与产 KPC 肺炎克雷伯菌碳青霉烯类耐药升高相关的遗传因素。
Antimicrob Agents Chemother. 2010 Oct;54(10):4201-7. doi: 10.1128/AAC.00008-10. Epub 2010 Jul 26.
4
Prospective observational study of the impact of VIM-1 metallo-beta-lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections.VIM-1金属β-内酰胺酶对肺炎克雷伯菌血流感染患者预后影响的前瞻性观察研究。
Antimicrob Agents Chemother. 2009 May;53(5):1868-73. doi: 10.1128/AAC.00782-08. Epub 2009 Feb 17.
5
Klebsiella pneumoniae isolate producing at least eight different beta-lactamases, including AmpC and KPC beta-lactamases.肺炎克雷伯菌分离株产生至少八种不同的β-内酰胺酶，包括AmpC和KPCβ-内酰胺酶。
Antimicrob Agents Chemother. 2007 Feb;51(2):800-1. doi: 10.1128/AAC.01143-06. Epub 2006 Dec 4.
6
Carbapenem resistance in Klebsiella pneumoniae not detected by automated susceptibility testing.自动药敏试验未检测到肺炎克雷伯菌对碳青霉烯类药物的耐药性。
Emerg Infect Dis. 2006 Aug;12(8):1209-13. doi: 10.3201/eid1208.060291.
7
Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium.耐碳青霉烯类肺炎克雷伯菌在纽约市的快速传播：对我们抗生素储备的新威胁。
Arch Intern Med. 2005 Jun 27;165(12):1430-5. doi: 10.1001/archinte.165.12.1430.
8
Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.从一株耐碳青霉烯类的肺炎克雷伯菌中分离出的新型碳青霉烯水解β-内酰胺酶KPC-1
Antimicrob Agents Chemother. 2001 Apr;45(4):1151-61. doi: 10.1128/AAC.45.4.1151-1161.2001.