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产碳青霉烯酶肠杆菌科细菌对头孢吡肟敏感的检测——参考方法。

Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae testing susceptible to cefepime by reference methods.

机构信息

Instituto de Microbiologia Paulo de Góes da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

J Clin Microbiol. 2013 Jul;51(7):2388-90. doi: 10.1128/JCM.00640-13. Epub 2013 Apr 24.

DOI:10.1128/JCM.00640-13
PMID:23616458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3697684/
Abstract

β-Lactam susceptibility of 499 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, determined by reference broth microdilution, demonstrated that 14.4% of isolates were categorized as cefepime susceptible according to current CLSI breakpoints. Ceftazidime- and meropenem-susceptible isolates were also observed (2.6 and 3.0%, respectively). Cefepime-susceptible KPC-producing isolates may confuse laboratory staff and clinicians in their therapeutic choices.

摘要

499 株产碳青霉烯酶肺炎克雷伯菌（KPC）肠杆菌科细菌的β-内酰胺类药物敏感性，采用参考肉汤微量稀释法进行检测，根据现行 CLSI 折点标准，14.4%的分离株被归类为头孢吡肟敏感。还观察到头孢他啶和亚胺培南敏感的分离株（分别为 2.6%和 3.0%）。产头孢吡肟敏感的 KPC 分离株可能会在治疗选择方面混淆实验室工作人员和临床医生。

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本文引用的文献

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Clin Infect Dis. 2013 Feb;56(4):488-95. doi: 10.1093/cid/cis916. Epub 2012 Oct 22.
2
Production of KPC-2 alone does not always result in β-lactam MICs representing resistance in gram-negative pathogens.单独产生KPC-2并不总是导致革兰氏阴性病原体中代表耐药性的β-内酰胺最低抑菌浓度（MIC）。
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Identification and screening of carbapenemase-producing Enterobacteriaceae.碳青霉烯酶肠杆菌科的鉴定和筛选。
Clin Microbiol Infect. 2012 May;18(5):432-8. doi: 10.1111/j.1469-0691.2012.03815.x.
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Are susceptibility tests enough, or should laboratories still seek ESBLs and carbapenemases directly?药敏试验就足够了吗，还是实验室仍应直接检测超广谱β-内酰胺酶（ESBLs）和碳青霉烯酶？
J Antimicrob Chemother. 2012 Jul;67(7):1569-77. doi: 10.1093/jac/dks088. Epub 2012 Mar 29.
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Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection.产碳青霉烯酶肺炎克雷伯菌（KPCs）的检测与治疗选择：一种多重耐药感染的新兴病因。
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