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芬兰中耳炎疫苗试验中的急性中耳炎置换和复发。

Acute otitis media replacement and recurrence in the Finnish otitis media vaccine trial.

机构信息

Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

出版信息

Clin Infect Dis. 2012 Dec;55(12):1673-6. doi: 10.1093/cid/cis799. Epub 2012 Sep 12.

DOI:10.1093/cid/cis799
PMID:22972864
Abstract

We reanalyzed the 7-valent pneumococcal conjugate vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement due to other pathogens and AOM recurrence. We found evidence of replacement disease occurring early during the trial follow-up and little vaccine impact on recurrent overall AOM episodes.

摘要

我们重新分析了 7 价肺炎球菌结合疫苗试验 FinOM 预防急性中耳炎（AOM）的结果，重点关注因其他病原体引起的疾病替代和 AOM 复发。我们发现试验随访早期出现疾病替代的证据，疫苗对总复发 AOM 发作的影响很小。

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