B-(3,3-二氟烯丙基)二异松蒎基硼烷用于醛的对映选择性氟烯丙基硼化反应。
B-(3,3-difluoroallyl)diisopinocampheylborane for the enantioselective fluoroallylboration of aldehydes.
机构信息
Herbert C. Brown Center for Borane Research, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, USA.
出版信息
J Org Chem. 2012 Oct 19;77(20):9329-33. doi: 10.1021/jo300970z. Epub 2012 Oct 1.
PMID:22973971
Abstract
The fluoroallylboration of aldehydes with B-(3,3-difluoroallyl)diisopinocampheylborane, which was prepared via the hydroboration of 1,1-difluoroallene, provides chiral 2,2-gem-difluorinated homoallylic alcohols in good yields and 91-97% ee.
摘要
通过 1,1-二氟丙烯的硼氢化反应制备的 B-(3,3-二氟烯丙基)二异松蒎基硼烷与醛的氟烯丙基硼化反应，以良好的收率和 91-97%的对映选择性提供了手性 2,2-位双氟代偕二氟烯丙醇。
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