Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA.
Obes Surg. 2012 Dec;22(12):1884-92. doi: 10.1007/s11695-012-0749-2.
Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment for morbid obesity. Increased alcohol abuse after RYGB resulted in recommendations to exclude patients with alcohol abuse histories from RYGB. The purpose of our study was to examine the effects of a RYGB on ethanol intake in diet-induced obese rats (high-fat diet).
The animals underwent RYGB and were habituated along with their sham-operated obese controls and with lean rats to increasing concentrations of ethanol in a two-bottle choice paradigm.
RYGB rats' daily consumption of ethanol averaged 2 g/kg at 2% habituation and 3.8 g/kg at 4% habituation, twice as much as sham-operated obese controls and 50% more than normal-diet lean controls. Obese controls drank on average 1 g/kg of ethanol (2 and 4%), significantly less (50%) than lean controls did. RYGB rats when given higher ethanol concentrations (6 and 8%) or no ethanol drank significantly more water than lean and obese controls did (66 and 100%, respectively), and their enhanced total fluid intake was associated with increased food intake, which was significantly higher than in lean (66% more calories; food + alcohol) and obese controls (44% more calories). The lower alcohol intake in the obese controls than in the lean rats suggests that obesity may interfere with alcohol's rewarding effects and RYGB may remove this protective effect.
The overall enhancement of consummatory behaviors (both ethanol and water) suggests that RYGB may facilitate alcohol consumption, which in vulnerable individuals could lead to abuse and addiction.
Roux-en-Y 胃旁路手术（RYGB）是治疗病态肥胖的有效方法。RYGB 后酗酒增加，导致建议将有酗酒史的患者排除在 RYGB 之外。我们研究的目的是检查 RYGB 对饮食诱导肥胖大鼠（高脂肪饮食）乙醇摄入的影响。
动物接受 RYGB，并与假手术肥胖对照组和正常饮食瘦对照组一起适应在双瓶选择范式中增加乙醇浓度。
RYGB 大鼠在 2%适应期的平均乙醇日摄入量为 2g/kg，在 4%适应期的平均乙醇日摄入量为 3.8g/kg，是假手术肥胖对照组的两倍，比正常饮食瘦对照组高 50%。肥胖对照组平均摄入 1g/kg 的乙醇（2%和 4%），明显低于瘦对照组。RYGB 大鼠在给予更高浓度的乙醇（6%和 8%）或没有乙醇时，比瘦对照组和肥胖对照组分别多喝 66%和 100%的水，并且它们增加的总液体摄入量与增加的食物摄入量相关，这显著高于瘦对照组（66%的卡路里；食物+酒精）和肥胖对照组（44%的卡路里）。肥胖对照组的乙醇摄入量低于瘦对照组，这表明肥胖可能会干扰酒精的奖赏作用，而 RYGB 可能会消除这种保护作用。
总体上增强了摄取行为（乙醇和水），这表明 RYGB 可能会促进酒精消费，这在易受影响的个体中可能导致滥用和成瘾。
