Patil Santosh, Khaandelwal Suneet, Doni Bharati, Rahuman Farzan, Kaswan Sumita
Department of Oral Medicine and Radiology, Jodhpur National University, Jodhpur, India.
Oral Health Dent Manag. 2012 Sep;11(3):100-6.
To determine the nature, incidence, and severity of oral manifestations that occur in chronic renal failure (CRF) in patients attending two hospitals in North Karnataka, in comparison with healthy, disease-free controls.
The study was carried out with 200 individuals (100 CRF patients and 100 controls). The case group was randomly selected from a population of CRF patients whose glomerular filtration rate (GFR) values were between 15-30 mL/min; the control group was selected in the same age group with normal GFR and was apparently disease free. The patients were asked about dry mouth, taste and halitosis, and mucosal pain, and were examined for oral changes such as tongue coating, pallor, ulceration and enamel hypoplasia. The results obtained from the study were then compared with various other similar studies.
The most common oral findings in the CRF patients were dry mouth (91%), pallor (87%), altered taste (42%), and halitosis (34%). CRF patients showed significantly more oral changes than those in the control group. These changes could be attributed to metabolic disturbances due to renal failure.
In the patients studied, the impact of CRF on the oral cavity was evidenced by significant oral changes, which pointed to an inter-relationship between oral health and CRF. Further studies are required to relate the extent of such changes with disease progression.
确定北卡纳塔克邦两家医院的慢性肾衰竭（CRF）患者口腔表现的性质、发生率及严重程度，并与健康且无疾病的对照组进行比较。
该研究纳入了200名个体（100名CRF患者和100名对照组）。病例组从肾小球滤过率（GFR）值在15 - 30 mL/分钟之间的CRF患者群体中随机选取；对照组在相同年龄组中选取，GFR正常且明显无疾病。询问患者口干、味觉和口臭以及黏膜疼痛情况，并检查口腔变化，如舌苔、苍白、溃疡和釉质发育不全。然后将研究所得结果与其他各种类似研究进行比较。
CRF患者最常见的口腔表现为口干（91%）、苍白（87%）、味觉改变（42%）和口臭（34%）。CRF患者的口腔变化明显多于对照组。这些变化可归因于肾衰竭导致的代谢紊乱。
在所研究的患者中，CRF对口腔的影响表现为明显的口腔变化，这表明口腔健康与CRF之间存在相互关系。需要进一步研究将此类变化的程度与疾病进展联系起来。
