Chvapil M, Eskelson C D, Stiffel V, Owen J A
Arch Environ Health. 1979 Nov-Dec;34(6):402-6. doi: 10.1080/00039896.1979.10667440.
A group of 200 g male Sprague-Dawley rats was injected with 75 mg of quartz (less than 5 mu particle size) and changes in lung DNA, noncollagenous protein, total lipids, and collagen were studied after 6, 24, 72, 96, and 144 hr. Another group of rats received 10, 30, 59, and 75 mg quartz and the above lung analysis was performed 6 days later. Control rats received saline only. Both sets of experiments indicate that striking changes in the above parameters occur very early. The sequence of statistically significant changes was: lung weight (24 hr), DNA (24 hr), noncollagenous proteins (72 hr), total lipids (72 hr), collagen (144 hr). At the dose of 30 mg quartz/lung all the above parameters were significantly increased within 6 days after the lung injury. It is proposed that in early stages of experimental silicosis an excessive amount of collagen accumulates in the lung. Later, some of the deposited collagen is resorbed. This indicates that in the course of the silicotic fibroproliferative inflammation, the balance between collagen deposition and degradation varies.
给一组200克重的雄性斯普拉格-道利大鼠注射75毫克石英（粒径小于5微米），并在6、24、72、96和144小时后研究肺组织中DNA、非胶原蛋白、总脂质和胶原蛋白的变化。另一组大鼠分别接受10、30、59和75毫克石英注射，并在6天后进行上述肺组织分析。对照大鼠仅接受生理盐水注射。两组实验均表明，上述参数的显著变化在很早的时候就会出现。具有统计学意义的变化顺序为：肺重量（24小时）、DNA（24小时）、非胶原蛋白（72小时）、总脂质（72小时）、胶原蛋白（144小时）。在每只肺注射30毫克石英的剂量下，肺损伤后6天内所有上述参数均显著增加。有人提出，在实验性矽肺的早期阶段，肺中会积累过量的胶原蛋白。后来，一些沉积的胶原蛋白会被吸收。这表明在矽肺纤维化增殖性炎症过程中，胶原蛋白沉积与降解之间的平衡是变化的。
