Hervig T, Vølundardottir T, Bakken A M, Farstad M
Blood Bank, Haukeland Hospital, Bergen, Norway.
Clin Chem. 1990 Jan;36(1):28-31.
Measurements of endogenous serotonin and the thrombin-induced serotonin release reaction in platelet concentrates were compared with other methods of quality control: particle counting and pH and gas analyses. A discrepancy between the serotonin release reaction and the other data was observed after seven days of storage. The decline in the release reaction was not predictable from pH measurements or the number of platelets or leukocytes in the concentrate. There was a significant positive correlation between endogenous serotonin content and the thrombin-induced serotonin secretion after seven days of storage. We conclude that the current methods for routine control of platelet concentrates may not ensure the quality of the product after it has been stored for seven days. The thrombin-induced serotonin release may provide a valuable addition to the battery of tests available.
颗粒计数、pH值和气体分析。在储存七天后，观察到血清素释放反应与其他数据之间存在差异。从pH值测量或浓缩物中血小板或白细胞的数量无法预测释放反应的下降。储存七天后，内源性血清素含量与凝血酶诱导的血清素分泌之间存在显著正相关。我们得出结论，目前用于血小板浓缩物常规控制的方法可能无法确保产品在储存七天后的质量。凝血酶诱导的血清素释放可能为现有的一系列检测提供有价值的补充。
