Laan B J, van den Heiligenberg S M, Hemelaar M
Westfriesgasthuis, Hoorn.
Ned Tijdschr Geneeskd. 2016;160:D480.
Classical Meigs' syndrome consists of the triad of an ovarian fibroma, ascites and pleural effusion. A characteristic of the syndrome is that the excess fluid is resorbed after surgical resection of the tumour.
A 49-year-old woman was admitted to accident and emergency department in a neglected, cachectic and hypothermic condition. A CT scan revealed an ovarian tumour, ascites and a right-sided pleural effusion. The level of the tumour marker CA-125 was also greatly elevated. Our initial working diagnosis was, therefore, 'high-grade ovarian carcinoma', but on repeated testing no malignant cells were found in the aspirated fluid. We suspected Meigs' syndrome. We first ensured that her general and nutritional condition improved; then she underwent a bilateral adnexectomy. A fibrothecoma was found in each ovary. The ascites and pleural effusion resolved following surgery and the patient recovered well.
The clinical picture of Meigs' syndrome can resemble that of high-grade ovarian carcinoma. This syndrome should be included in the differential diagnosis in patients with an ovarian tumour, ascites and, possibly, pleural effusion.
经典的梅格斯综合征由卵巢纤维瘤、腹水和胸腔积液三联征组成。该综合征的一个特点是,肿瘤手术切除后多余的液体可被吸收。
一名49岁女性因被忽视、消瘦和体温过低而入住急诊部。CT扫描显示有卵巢肿瘤、腹水和右侧胸腔积液。肿瘤标志物CA-125水平也大幅升高。因此,我们最初的初步诊断是“高级别卵巢癌”,但反复检测发现抽吸液中未发现恶性细胞。我们怀疑是梅格斯综合征。我们首先确保她的一般状况和营养状况得到改善;然后她接受了双侧附件切除术。每个卵巢均发现纤维卵泡膜瘤。术后腹水和胸腔积液消退,患者恢复良好。
梅格斯综合征的临床表现可能类似于高级别卵巢癌。对于患有卵巢肿瘤、腹水以及可能伴有胸腔积液的患者,该综合征应列入鉴别诊断。