Bradley T D, Mateika J, Li D, Avendano M, Goldstein R S
Division of Respirology, West Park Hospital, Toronto, Ontario, Canada.
Chest. 1990 Feb;97(2):308-12. doi: 10.1378/chest.97.2.308.
Arterial oxyhemoglobin saturation (SaO2) falls to a variable extent during sleep in patients with COPD. These nocturnal falls in SaO2 may contribute to the development of pulmonary hypertension, nocturnal cardiac arrhythmias, and death during sleep. In order to determine which physiologic factors measured during wakefulness might contribute to the development of nocturnal hypoxemia, we performed multiple stepwise linear regression analyses in 48 patients with stable COPD with mean and lowest nocturnal SaO2 as dependent variables. It was concluded that the two chief variables, measured while awake, which are associated with alterations in nocturnal oxygenation in patients with COPD are baseline awake SaO2 and PaCO2. Hypercapnia appears to be a risk factor for the development of nocturnal hypoxemia in patients who are normoxic while awake.
慢性阻塞性肺疾病（COPD）患者睡眠期间动脉血氧血红蛋白饱和度（SaO2）会不同程度下降。这些夜间SaO2下降可能会导致肺动脉高压、夜间心律失常以及睡眠期间死亡。为了确定清醒时测量的哪些生理因素可能导致夜间低氧血症的发生，我们对48例稳定期COPD患者进行了多步线性回归分析，以平均夜间SaO2和最低夜间SaO2作为因变量。得出的结论是，清醒时测量的与COPD患者夜间氧合改变相关的两个主要变量是清醒时基线SaO2和动脉血二氧化碳分压（PaCO2）。高碳酸血症似乎是清醒时血氧正常的患者发生夜间低氧血症的一个危险因素。
