糖尿病 β 细胞：生存还是毁灭？
Diabetic β Cells: To Be or Not To Be?
机构信息
Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
出版信息
Cell. 2012 Sep 14;150(6):1103-4. doi: 10.1016/j.cell.2012.08.021.
Abstract
β cell dysfunction with subsequent apoptosis is considered a significant contributor to the development of type 2 diabetes. Emerging data from Talchai et al. suggest β cell dedifferentiation as an alternative mechanism of insulin insufficiency that might be more amenable to intervention in at least a subset of patients.
摘要
β 细胞功能障碍随后发生细胞凋亡被认为是导致 2 型糖尿病发生的重要因素。Talchai 等人的新数据表明，β 细胞去分化是胰岛素分泌不足的另一种机制，至少在一部分患者中，这种机制可能更容易干预。
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本文引用的文献
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Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.胰腺 β 细胞去分化作为糖尿病 β 细胞衰竭的一种机制。
Cell. 2012 Sep 14;150(6):1223-34. doi: 10.1016/j.cell.2012.07.029.
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