Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.
Cell Metab. 2012 Oct 3;16(4):420-34. doi: 10.1016/j.cmet.2012.06.017. Epub 2012 Sep 13.
Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical cellular functions. The past two decades have seen significant advances in sphingolipid research, and in 2010 a first sphingolipid receptor modulator was employed as a human therapeutic. Furthermore, cellular signaling mechanisms regulated by sphingolipids are being recognized as critical players in metabolic diseases. This review focuses on recent advances in cellular and physiological mechanisms of sphingolipid regulation and how sphingolipid signaling influences metabolic diseases. Progress in this area may contribute to new understanding and therapeutic options in complex diseases such as atherosclerosis, diabetes, metabolic syndromes, and cancer.
鞘脂类,真核生物中普遍存在的膜脂质,执行着无数关键的细胞功能。在过去的二十年中,鞘脂类的研究取得了重大进展,2010 年,第一种鞘脂类受体调节剂被用于人类治疗。此外,由鞘脂类调节的细胞信号转导机制被认为是代谢性疾病的关键因素。这篇综述重点介绍了鞘脂类调节的细胞和生理机制的最新进展,以及鞘脂类信号如何影响代谢性疾病。这一领域的进展可能有助于人们对复杂疾病(如动脉粥样硬化、糖尿病、代谢综合征和癌症)有新的认识和治疗选择。