用心血管磁共振波谱测量心肌能量代谢。

Measuring Myocardial Energetics with Cardiovascular Magnetic Resonance Spectroscopy.

机构信息

Aix-Marseille Université, CNRS, CRMBM, Faculté de Médecine, 27 BVD Jean Moulin, Marseille 13005, France; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

Heart Fail Clin. 2021 Jan;17(1):149-156. doi: 10.1016/j.hfc.2020.08.011.

DOI:10.1016/j.hfc.2020.08.011

PMID:33220883

Abstract

The heart has the highest energy demands per gram of any organ in the body and energy metabolism fuels normal contractile function. Metabolic inflexibility and impairment of myocardial energetics occur with several common cardiac diseases, including ischemia and heart failure. This review explores several decades of innovation in cardiac magnetic resonance spectroscopy modalities and their use to noninvasively identify and quantify metabolic derangements in the normal, failing, and diseased heart. The implications of this noninvasive modality for predicting significant clinical outcomes and guiding future investigation and therapies to improve patient care are discussed.

摘要

心脏是人体中每克组织需能最高的器官，能量代谢为心肌的正常收缩功能提供燃料。多种常见的心脏疾病（包括缺血和心力衰竭）会导致代谢灵活性降低和心肌能量学受损。本综述探讨了几十年来心脏磁共振波谱技术的创新及其在无创性识别和量化正常、衰竭和患病心脏代谢异常中的应用。讨论了这种无创技术对预测重大临床结局以及指导未来研究和治疗以改善患者治疗的意义。