Pampiglione J S, Mills C, Campbell S, Steer C, Kingsland C, Mason B A
Hallam Medical Centre, London, United Kingdom.
Fertil Steril. 1990 Feb;53(2):306-10. doi: 10.1016/s0015-0282(16)53286-5.
To assess the value of reinseminating human oocytes, the results of 1,662 embryo transfers were analyzed. In 1,460 transfers embryos arose from oocytes that had fertilized and cleaved after initial insemination. The pregnancy rate was significantly higher than in transfers of embryos (n = 76) resulting solely from reinseminated oocytes (27% versus 3%). Adding reinseminated embryos to those fertilizing on initial insemination at transfer failed to raise the pregnancy rate. Only 2 of 158 (1.3%) reinseminated embryos implanted compared with 540 of 4,181 (12.9%) fertilized and cleaved on initial insemination (P less than 0.001). Reinseminated embryos do occasionally produce viable pregnancies. It is therefore worth considering replacement of these embryos if initial fertilization has entirely failed. Patients should be counseled as to the low chance of implantation with these embryos.
为评估人类卵母细胞再授精的价值，分析了1662例胚胎移植的结果。在1460例移植中，胚胎来自初次授精后已受精并分裂的卵母细胞。其妊娠率显著高于仅来自再授精卵母细胞的胚胎移植（76例）（27%对3%）。在移植时将再授精胚胎添加到初次授精时受精的胚胎中未能提高妊娠率。158例再授精胚胎中只有2例（1.3%）着床，而初次授精时受精并分裂的4181例中有540例（12.9%）着床（P<0.001）。再授精胚胎偶尔会产生存活妊娠。因此，如果初次受精完全失败，值得考虑移植这些胚胎。应向患者说明这些胚胎着床可能性低的情况。
