• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

梓醇对培养细胞和小鼠的放射防护作用。

Radio-protective effect of catalpol in cultured cells and mice.

机构信息

Department of Traditional Chinese Medicine, Changhai Hospital, 174 Changhai Road, Shanghai 200433, PR China.

出版信息

J Radiat Res. 2013 Jan;54(1):76-82. doi: 10.1093/jrr/rrs080. Epub 2012 Sep 14.

DOI:10.1093/jrr/rrs080
PMID:22984279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3534281/
Abstract

Ionizing radiation can induce DNA damage and cell death by generating reactive oxygen species (ROS). The objective of this study was to investigate the radio-protective effect of catalpol (a main bioactive component in the traditional Chinese Rehmannia) on irradiated cells and mice. We found that treating cells with catalpol (25-100 μg/ml) before irradiation could significantly inhibit ionizing radiation (IR)-induced human lymphocyte AHH-1 cells apoptosis and increase cells viability in vitro. At the same time our study also showed that catalpol (25-100 mg/kg) reduced morphological damage of the gastrointestinal tract by 15.6%, 33.3% and 44.4%, respectively compared with the radiation-induced group, decreased plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine (8-OHdG) levels and increased plasma endogenous antioxidants and peripheral white blood cells and platelets in vivo. These results suggest that catalpol possesses notable radio-protective activity, which might be related to its effect of reducing ROS.

摘要

电离辐射可以通过产生活性氧（ROS）来诱导 DNA 损伤和细胞死亡。本研究的目的是探讨梓醇（传统中药地黄的主要生物活性成分）对辐射细胞和小鼠的放射保护作用。我们发现，在照射前用梓醇（25-100μg/ml）处理细胞，可显著抑制电离辐射（IR）诱导的人淋巴细胞 AHH-1 细胞凋亡，并提高体外细胞活力。同时，我们的研究还表明，梓醇（25-100mg/kg）可分别减少 15.6%、33.3%和 44.4%的胃肠道形态损伤，降低血浆丙二醛（MDA）、肠 8-羟基脱氧鸟苷（8-OHdG）水平，增加体内血浆内源性抗氧化剂和外周白细胞及血小板。这些结果表明梓醇具有显著的放射保护活性，这可能与其降低 ROS 的作用有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/52df9fb98d8b/rrs08006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/e7db0ce8eb29/rrs08001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/8891a2ccb161/rrs08002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/b0b73aed451b/rrs08003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/7cde891789db/rrs08004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/d025de0e24d5/rrs08005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/52df9fb98d8b/rrs08006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/e7db0ce8eb29/rrs08001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/8891a2ccb161/rrs08002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/b0b73aed451b/rrs08003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/7cde891789db/rrs08004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/d025de0e24d5/rrs08005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ef/3534281/52df9fb98d8b/rrs08006.jpg

相似文献

1
Radio-protective effect of catalpol in cultured cells and mice.梓醇对培养细胞和小鼠的放射防护作用。
J Radiat Res. 2013 Jan;54(1):76-82. doi: 10.1093/jrr/rrs080. Epub 2012 Sep 14.
2
Radioprotective effect of hydrogen in cultured cells and mice.氢气对培养细胞和小鼠的辐射防护作用。
Free Radic Res. 2010 Mar;44(3):275-82. doi: 10.3109/10715760903468758.
3
Ascorbic acid 2-glucocide reduces micronucleus induction in distant splenic T lymphocytes following head irradiation.抗坏血酸 2-葡萄糖苷降低头部照射后远处脾脏 T 淋巴细胞微核的诱导。
Mutat Res. 2010 Jan;695(1-2):69-74. doi: 10.1016/j.mrgentox.2009.12.002. Epub 2009 Dec 16.
4
Radioprotector WR-2721 and mitigating peptidoglycan synergistically promote mouse survival through the amelioration of intestinal and bone marrow damage.辐射防护剂WR-2721和减轻肽聚糖通过改善肠道和骨髓损伤协同促进小鼠存活。
J Radiat Res. 2015 Mar;56(2):278-86. doi: 10.1093/jrr/rru100. Epub 2015 Jan 23.
5
Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro.梓醇通过激活体内和体外的 SIRT1 信号通路缓解阿霉素肾病。
Br J Pharmacol. 2019 Dec;176(23):4558-4573. doi: 10.1111/bph.14822. Epub 2019 Dec 11.
6
Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice.梓醇对脂多糖诱导的小鼠急性肺损伤的保护作用。
Int Immunopharmacol. 2014 Dec;23(2):400-6. doi: 10.1016/j.intimp.2014.07.011. Epub 2014 Jul 22.
7
Global gene expression analysis in liver of db/db mice treated with catalpol.用梓醇处理 db/db 小鼠肝脏的全基因表达分析。
Chin J Nat Med. 2018 Aug;16(8):590-598. doi: 10.1016/S1875-5364(18)30096-7.
8
Effects of recombinant human granulocyte colony-stimulating factor on central and peripheral T lymphocyte reconstitution after sublethal irradiation in mice.重组人粒细胞集落刺激因子对亚致死剂量照射后小鼠中枢和外周 T 淋巴细胞重建的影响。
J Radiat Res. 2013 Jan;54(1):83-91. doi: 10.1093/jrr/rrs082. Epub 2012 Sep 20.
9
Protective effects of tetrahydropalmatine against gamma-radiation induced damage to human endothelial cells.延胡索乙素对γ射线致人血管内皮细胞损伤的保护作用。
Life Sci. 2010 Jul 3;87(1-2):55-63. doi: 10.1016/j.lfs.2010.05.011. Epub 2010 May 26.
10
Catalpol protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytotoxicity in osteoblastic MC3T3-E1 cells.梓醇可预防 2,3,7,8-四氯二苯并对二恶英诱导的成骨细胞 MC3T3-E1 细胞毒性。
J Appl Toxicol. 2019 Dec;39(12):1710-1719. doi: 10.1002/jat.3896. Epub 2019 Aug 19.

引用本文的文献

1
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.梓醇通过激活晚发性阿尔茨海默病患者永生化淋巴细胞与SKNMC细胞共培养模型中的Keap1-Nrf2/ARE信号通路，减轻淀粉样蛋白生成和神经元氧化应激损伤。
Iran J Basic Med Sci. 2024;27(12):1547-1557. doi: 10.22038/ijbms.2024.78543.16982.
2
The role of HIF-1α-mediated autophagy in ionizing radiation-induced testicular injury.低氧诱导因子 1α 介导体细胞自噬在电离辐射诱导睾丸损伤中的作用。
J Mol Histol. 2023 Oct;54(5):439-451. doi: 10.1007/s10735-023-10153-6. Epub 2023 Sep 20.
3

本文引用的文献

1
Efficacy of catalpol as protectant against oxidative stress and mitochondrial dysfunction on rotenone-induced toxicity in mice brain.梓醇对鱼藤酮诱导的小鼠脑毒性氧化应激和线粒体功能障碍的保护作用。
Environ Toxicol Pharmacol. 2007 May;23(3):314-8. doi: 10.1016/j.etap.2006.11.012. Epub 2006 Dec 9.
2
Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes.橙皮苷对γ射线诱导的培养人外周血淋巴细胞细胞损伤的辐射防护功效研究。
Mutat Res. 2009 May 31;676(1-2):54-61. doi: 10.1016/j.mrgentox.2009.03.005. Epub 2009 Mar 31.
3
Qualitative and Quantitative Analysis of Secondary Metabolites in Morphological Parts of Paulownia Clon In Vitro 112 and Their Anticoagulant Properties in Whole Human Blood.
泡桐无性系 112 体外形态部位次生代谢产物的定性定量分析及其在全人血中的抗凝性能。
Molecules. 2022 Feb 1;27(3):980. doi: 10.3390/molecules27030980.
4
Study of Terpenoid Synthesis and Prenyltransferase in Roots of Based on iTRAQ Quantitative Proteomics.基于iTRAQ定量蛋白质组学的[植物名称]根中萜类化合物合成及异戊烯基转移酶的研究 （注：原文中“Based on iTRAQ Quantitative Proteomics”前缺少具体植物名称，翻译时根据语境补充了[植物名称]）
Front Plant Sci. 2021 Aug 4;12:693758. doi: 10.3389/fpls.2021.693758. eCollection 2021.
5
Phytochemical profile of (Thunb). Steud.（Thunb.）Steud.的植物化学特征
Phytochem Rev. 2015;14(5):799-833. doi: 10.1007/s11101-014-9376-y. Epub 2014 Aug 29.
6
Catalpol alleviates renal damage by improving lipid metabolism in diabetic db/db mice.梓醇通过改善糖尿病db/db小鼠的脂质代谢来减轻肾脏损伤。
Am J Transl Res. 2018 Jun 15;10(6):1750-1761. eCollection 2018.
7
Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells.梓醇通过促进瑞典突变型APP过表达的N2a细胞中APP的α-切割来抑制淀粉样β蛋白的生成。
Front Aging Neurosci. 2018 Mar 19;10:66. doi: 10.3389/fnagi.2018.00066. eCollection 2018.
8
Catalpol ameliorates diabetic atherosclerosis in diabetic rabbits.梓醇改善糖尿病兔的糖尿病性动脉粥样硬化。
Am J Transl Res. 2016 Oct 15;8(10):4278-4288. eCollection 2016.
9
Amelioration of Diabetic Mouse Nephropathy by Catalpol Correlates with Down-Regulation of Grb10 Expression and Activation of Insulin-Like Growth Factor 1 / Insulin-Like Growth Factor 1 Receptor Signaling.梓醇改善糖尿病小鼠肾病与Grb10表达下调及胰岛素样生长因子1/胰岛素样生长因子1受体信号激活相关。
PLoS One. 2016 Mar 17;11(3):e0151857. doi: 10.1371/journal.pone.0151857. eCollection 2016.
10
Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt-eNOS signaling and inflammation.梓醇通过抑制PI3K/Akt-eNOS信号传导和炎症反应保护小鼠免受肾缺血/再灌注损伤。
Int J Clin Exp Med. 2015 Feb 15;8(2):2038-44. eCollection 2015.
[Effects of Sisheng Decoction on spontaneous activity and serum concentration of malondialdehyde in mice with yin deficiency syndrome].
四生汤对阴虚证小鼠自发活动及血清丙二醛含量的影响
Zhong Xi Yi Jie He Xue Bao. 2008 Oct;6(10):1029-33. doi: 10.3736/jcim20081008.
4
Protective effects of catalpol against H2O2-induced oxidative stress in astrocytes primary cultures.梓醇对原代培养星形胶质细胞中过氧化氢诱导的氧化应激的保护作用。
Neurosci Lett. 2008 Sep 19;442(3):224-7. doi: 10.1016/j.neulet.2008.07.029. Epub 2008 Jul 17.
5
alpha-Tocopherol, MDA-HNE and 8-OHdG levels in liver and heart mitochondria of adriamycin-treated rats fed with alcohol-free beer.用无醇啤酒喂养的阿霉素处理大鼠肝脏和心脏线粒体中的α-生育酚、丙二醛-羟壬烯醛和8-羟基脱氧鸟苷水平。
Toxicology. 2008 Jul 30;249(2-3):97-101. doi: 10.1016/j.tox.2008.04.010. Epub 2008 Apr 22.
6
Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa.地黄梓醇神经保护作用的进一步药理学证据。
Phytomedicine. 2008 Jun;15(6-7):484-90. doi: 10.1016/j.phymed.2008.01.001. Epub 2008 Feb 20.
7
Trends in the development of radioprotective agents.辐射防护剂的发展趋势。
Drug Discov Today. 2007 Oct;12(19-20):794-805. doi: 10.1016/j.drudis.2007.07.017. Epub 2007 Sep 10.
8
Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol.Taq DNA聚合酶抑制剂梓醇的新型抗增殖类似物。
Bioorg Med Chem Lett. 2007 Mar 1;17(5):1332-5. doi: 10.1016/j.bmcl.2006.11.086. Epub 2006 Dec 3.
9
Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitogen-activated protein kinases.芍药苷对辐射诱导的细胞损伤的保护作用涉及活性氧和丝裂原活化蛋白激酶的调节。
Int J Biochem Cell Biol. 2007;39(2):426-38. doi: 10.1016/j.biocel.2006.09.011. Epub 2006 Oct 12.
10
Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury.梓醇调节沙土鼠缺血性损伤后Bcl-2和Bax的表达并减轻细胞凋亡。
Brain Res. 2006 Oct 18;1115(1):179-85. doi: 10.1016/j.brainres.2006.07.063. Epub 2006 Aug 22.