Kamaratos Alexandros V, Tzirogiannis Konstantinos N, Iraklianou Stella A, Panoutsopoulos Georgios I, Kanellos Ilias E, Melidonis Andreas I
Diabetes Center, Tzanio General Hospital, Piraeus, GreeceDepartment of Nursing, University of Peloponnese, Orthias Artemidos and Plateon, Sparta, Lakonia, Greece.
Int Wound J. 2014 Jun;11(3):259-63. doi: 10.1111/j.1742-481X.2012.01082.x. Epub 2012 Sep 18.
In this study, we investigate the effect of manuka honey-impregnated dressings (MHID) on the healing of neuropathic diabetic foot ulcers (NDFU). A total of 63 Caucasians, type 2 diabetic patients followed up in the diabetic foot outpatient clinic comprised the study population. Patients were randomised in two groups as follows: group I patients were treated with MHID and group II patients were treated with conventional dressings (CD). The patients were followed up on a weekly basis for 16 weeks. Mean healing time was 31 ± 4 days in group I versus 43 ± 3 days in group II (P < 0·05). In group I patients 78·13% of ulcers became sterile during the first week versus 35·5% in group II patients; the corresponding percentages for weeks 2, 4 and 6 were 15·62% versus 38·7%, 6·25% versus 12·9% and 0% versus 12·9% respectively. The percent of ulcers healed did not differ significantly between groups (97% for MHID and 90% for CD). MHID represent an effective treatment for NDFU leading to a significant reduction in the time of healing and rapid disinfection of ulcers.
在本研究中，我们调查了麦卢卡蜂蜜浸渍敷料（MHID）对神经性糖尿病足溃疡（NDFU）愈合的影响。共有63名在糖尿病足门诊随访的2型糖尿病白种人患者构成了研究人群。患者被随机分为两组如下：第一组患者接受MHID治疗，第二组患者接受传统敷料（CD）治疗。患者每周随访一次，共16周。第一组的平均愈合时间为31±4天，而第二组为43±3天（P<0.05）。在第一组患者中，78.13%的溃疡在第一周内变为无菌，而第二组患者为35.5%；第2、4和6周的相应百分比分别为15.62%对38.7%、6.25%对12.9%和0%对12.9%。两组之间愈合的溃疡百分比无显著差异（MHID为97%，CD为90%）。MHID是治疗NDFU的一种有效方法，可显著缩短愈合时间并使溃疡快速消毒。
