National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan.
Vet Parasitol. 2013 Jan 16;191(1-2):1-10. doi: 10.1016/j.vetpar.2012.08.022. Epub 2012 Sep 4.
Fusidic acid known to has antibacterial, antifungal, and antimalarial activities. Fusidic acid blocks translation elongation factor G gene in Plasmodium falciparum. In the present study, the inhibitory effects of fusidic acid on the in vitro growth of bovine and equine Babesia parasites were evaluated. The inhibitory effect of fusidic acid on the in vivo growth of Babesia microti was also assessed. The in vitro growth of four Babesia species that were tested was significantly inhibited (P<0.05) by micromolar concentrations of fusidic acid (IC(50) values=144.8, 17.3, 33.3, and 56.25 μM for Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi, respectively). Combinations of fusidic acid with diminazene aceturate synergistically potentiated its inhibitory effects in vitro on B. bovis and B. caballi. In B. microti-infected mice, fusidic acid caused significant (P<0.05) inhibition of the growth of B. microti at the dose of 500 mg/kg BW relative to control group. These results indicate that fusidic acid might be incorporated in treatment of babesiosis.
已知夫西地酸具有抗菌、抗真菌和抗疟原虫活性。夫西地酸可阻断恶性疟原虫翻译延伸因子 G 基因。本研究评估了夫西地酸对牛和马巴贝斯虫寄生虫体外生长的抑制作用。还评估了夫西地酸对微小巴贝斯虫体内生长的抑制作用。四种被测试的巴贝斯虫物种的体外生长均被微摩尔浓度的夫西地酸显著抑制（P<0.05）（IC（50）值分别为 144.8、17.3、33.3 和 56.25 μM，用于牛巴贝斯虫、双芽巴贝斯虫、马巴贝斯虫和马媾疫锥虫）。夫西地酸与硝唑苯哒嗪联合使用可协同增强其对 B. bovis 和 B. caballi 的体外抑制作用。在感染微小巴贝斯虫的小鼠中，夫西地酸在 500mg/kgBW 的剂量下可显著（P<0.05）抑制微小巴贝斯虫的生长，与对照组相比。这些结果表明夫西地酸可能被纳入巴贝斯虫病的治疗中。
