Department of Dermatology, Cairo University, Cairo, Egypt.
Skin Pharmacol Physiol. 2013;26(1):2-7. doi: 10.1159/000342124. Epub 2012 Sep 11.
To investigate the role of paraoxonase 1 (PON1) and vitamin E in the pathogenesis of some autoimmune diseases, and to correlate their levels with the disease activity.
This randomized case control study was performed on 60 subjects: 45 patients [suffering from psoriasis, vitiligo and alopecia areata (AA) 15 patients each group] and 15 healthy controls. Venous blood and tissue biopsy were collected from each subject to estimate the levels of vitamin E and PON1.
All patients showed significantly lower levels of both PON1 and vitamin E in tissue and serum than the controls (p < 0.001).
An association between oxidative stress and pathogenesis of these autoimmune diseases is identified. Attenuation of oxidative stress might be a relevant therapeutic approach and it would be useful to recommend additional drugs with antioxidant effects in the treatment of these conditions.
研究对氧磷酶 1（PON1）和维生素 E 在某些自身免疫性疾病发病机制中的作用，并将其水平与疾病活动相关联。
本随机病例对照研究共纳入 60 名受试者：45 名患者（分别患有银屑病、白癜风和斑秃患者各 15 名）和 15 名健康对照者。从每位受试者采集静脉血和组织活检样本，以评估维生素 E 和 PON1 的水平。
所有患者的组织和血清中 PON1 和维生素 E 水平均明显低于对照组（p < 0.001）。
确定了氧化应激与这些自身免疫性疾病发病机制之间的关联。减轻氧化应激可能是一种相关的治疗方法，在治疗这些疾病时建议使用具有抗氧化作用的其他药物将是有益的。
