Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom.
Infect Immun. 2012 Dec;80(12):4216-22. doi: 10.1128/IAI.00559-12. Epub 2012 Sep 17.
Candida albicans is normally found as a commensal microbe, commonly colonizing the gastrointestinal tract in humans. However, this fungus can also cause mucosal and systemic infections once immune function is compromised. Dectin-1 is an innate pattern recognition receptor essential for the control of fungal infections in both mice and humans; however, its role in the control of C. albicans colonization of the gastrointestinal tract has not been defined. Here, we demonstrate that in mice dectin-1 is essential for the control of gastrointestinal invasion during systemic infection, with dectin-1 deficiency associating with impaired fungal clearance and dysregulated cytokine production. Surprisingly, however, following oral infection, dectin-1 was not required for the control of mucosal colonization of the gastrointestinal tract, in terms of either fungal burdens or cytokine response. Thus, in mice, dectin-1 is essential for controlling systemic infection with C. albicans but appears to be redundant for the control of gastrointestinal colonization.
白色念珠菌通常作为一种共生微生物存在，常见于人类的胃肠道定植。然而，一旦免疫功能受损，这种真菌也会引起黏膜和全身感染。Dectin-1 是一种先天模式识别受体，对于控制小鼠和人类的真菌感染至关重要；然而，它在控制白色念珠菌胃肠道定植中的作用尚未确定。在这里，我们证明在小鼠中，dectin-1 对于控制全身感染期间的胃肠道侵袭是必不可少的，dectin-1 缺陷与真菌清除受损和细胞因子产生失调有关。然而，令人惊讶的是，在口服感染后，dectin-1 对于控制胃肠道黏膜定植并不必需，无论是真菌负荷还是细胞因子反应。因此，在小鼠中，dectin-1 对于控制白色念珠菌的全身感染是必不可少的，但对于控制胃肠道定植似乎是多余的。
