Aquino Camila Catherine, Felício Andre C, Castro Pollyanna Celso Felipe de, Oliveira Ricardo Araujo, Silva Sonia Maria Cesar Azevedo, Borges Vanderci, Ferraz Henrique Ballalai
Movement Disorder Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo SP, Brazil.
Arq Neuropsiquiatr. 2012 Sep;70(9):662-6. doi: 10.1590/s0004-282x2012000900003.
It was to analyze clinical aspects of patients with blepharospasm, including outcomes of botulinum toxin treatment. Additionally, clinical characteristics of isolated blepharospasm were compared to those of blepharospasm plus other movement disorders.
Clinical data recorded during 17 years were reviewed. The variables included age, gender, age of onset, past medical history, head trauma, smoking history, family history of dystonia, severity, duration of botulinum toxin relief and adverse effects.
A total of 125 patients were included and 75.2% were female. The mean age of onset was 54.3 years; 89.6% of the individuals started with contractions in eye region, and 39.2% of them spread to lower face or neck. Isolated blepharospasm group was compared with blepharospasm-plus group for demographic and clinical features, and therapeutic outcomes, without significant differences. Botulinum toxin treatment improved the severity of contractions (p=0.01) with low rate of side effects (14%).
Both groups - isolated blepharospasm and blepharospasm-plus - shared similar results concerning epidemiology, clinical features and therapeutic response to botulinum toxin.
分析眼睑痉挛患者的临床情况，包括肉毒杆菌毒素治疗的效果。此外，将孤立性眼睑痉挛的临床特征与合并其他运动障碍的眼睑痉挛的临床特征进行比较。
回顾17年间记录的临床数据。变量包括年龄、性别、发病年龄、既往病史、头部外伤、吸烟史、肌张力障碍家族史、严重程度、肉毒杆菌毒素缓解持续时间及不良反应。
共纳入125例患者，75.2%为女性。平均发病年龄为54.3岁；89.6%的患者始于眼部区域收缩，其中39.2%蔓延至面部下部或颈部。对孤立性眼睑痉挛组和合并其他运动障碍的眼睑痉挛组的人口统计学和临床特征以及治疗效果进行比较，无显著差异。肉毒杆菌毒素治疗改善了收缩的严重程度（p=0.01），副作用发生率较低（14%）。
孤立性眼睑痉挛组和合并其他运动障碍的眼睑痉挛组在流行病学、临床特征及对肉毒杆菌毒素的治疗反应方面结果相似。
