Nat Immunol. 2012 Oct;13(10):942-3. doi: 10.1038/ni.2421.
The secretion of cytokines by helper T cells is affected by the cytokine environment and by costimulatory signals. Engagement of the receptor OX40 on T cells increases expression of the transcription factor TRAF6, activates the alternative transcription factor NF-κB pathway and induces the production of interleukin 9.
辅助性 T 细胞的细胞因子分泌受到细胞因子环境和共刺激信号的影响。T 细胞上 OX40 受体的结合会增加转录因子 TRAF6 的表达，激活替代性转录因子 NF-κB 途径，并诱导白细胞介素 9 的产生。
