Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Center, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia ; Division of Pharmacology, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Evid Based Complement Alternat Med. 2012;2012:948080. doi: 10.1155/2012/948080. Epub 2012 Sep 9.
Estrogen replacement therapy (ERT) is the main treatment postmenopausal osteoporosis. However, ERT causes serious side effects, such as cancers and thromboembolic problems. Labisia pumila var. alata (LPva) is a herb with potential as an alternative to ERT to prevent complications of osteoporosis, especially fragility fractures. This study was conducted to determine the effects of LPva on the biomechanical strength of femora exposed to osteoporosis due to estrogen deficiency, using the postmenopausal rat model. Thirty-two female rats were randomly divided into four groups: Sham-operated (Sham), ovariectomized control (OVXC), ovariectomized with Labisia pumila var. alata (LP), and ovariectomized with ERT (Premarin) (ERT). The LPva and ERT were administered via oral gavage daily at doses of 17.5 mg/kg and 64.5 μg/kg, respectively. Following two months of treatment, the rats were euthanized, and their right femora were prepared for bone biomechanical testing. The results showed that ovariectomy compromised the femoral strength, while LPva supplementation to the ovariectomized rats improved the femoral strength. Therefore, LPva may be as effective as ERT in preventing fractures due to estrogen-deficient osteoporosis.
雌激素替代疗法（ERT）是治疗绝经后骨质疏松症的主要方法。然而，ERT 会引起严重的副作用，如癌症和血栓栓塞问题。山兰（Labisia pumila var. alata，LPva）是一种具有替代 ERT 潜力的草药，可以预防骨质疏松症的并发症，特别是脆性骨折。本研究旨在使用绝经后大鼠模型，确定 LPva 对因雌激素缺乏导致骨质疏松的股骨生物力学强度的影响。32 只雌性大鼠被随机分为 4 组：假手术组（Sham）、去卵巢对照组（OVXC）、去卵巢加山兰组（LP）和去卵巢加雌激素替代疗法组（Premarin）（ERT）。LPva 和 ERT 分别通过口服灌胃每天给予 17.5mg/kg 和 64.5μg/kg 的剂量。治疗两个月后，对大鼠进行安乐死，并准备右侧股骨进行骨生物力学测试。结果表明，去卵巢会损害股骨强度，而 LPva 补充到去卵巢大鼠中则可以改善股骨强度。因此，LPva 预防雌激素缺乏性骨质疏松性骨折的效果可能与 ERT 相当。
