Department of Biochemistry, University of Missouri, Columbia, 65211, USA.
Annu Rev Microbiol. 2012;66:285-303. doi: 10.1146/annurev-micro-092611-150120.
This review focuses on the early years of molecular studies of bacterial chemotaxis and motility, beginning in the 1960s with Julius Adler's pioneering work. It describes key observations that established the field and made bacterial chemotaxis a paradigm for the molecular understanding of biological signaling. Consideration of those early years includes aspects of science seldom described in journals: the accidental findings, personal interactions, and scientific culture that often drive scientific progress.
这篇综述聚焦于细菌趋化性和运动性的分子研究早期,始于 20 世纪 60 年代 Julius Adler 的开创性工作。它描述了确立该领域的关键观察结果,并使细菌趋化性成为生物信号分子理解的范例。对这些早期的考虑包括科学期刊很少描述的方面:偶然发现、个人互动和科学文化,这些往往推动了科学的进步。