Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, OX3 7BN, UK.
Curr Opin Struct Biol. 2023 Apr;79:102565. doi: 10.1016/j.sbi.2023.102565. Epub 2023 Mar 1.
Bacterial chemosensory arrays have served as a model system for in-situ structure determination, clearly cataloguing the improvement of cryo-electron tomography (cryoET) over the past decade. In recent years, this has culminated in an accurately fitted atomistic model for the full-length core signalling unit (CSU) and numerous insights into the function of the transmembrane receptors responsible for signal transduction. Here, we review the achievements of the latest structural advances in bacterial chemosensory arrays and the developments which have made such advances possible.
细菌化学感觉阵列已成为原位结构测定的模型系统，清楚地列出了过去十年中冷冻电子断层扫描（cryoET）的改进。近年来，这最终导致了全长核心信号单元（CSU）的精确拟合原子模型，以及对负责信号转导的跨膜受体功能的许多深入了解。在这里，我们回顾了细菌化学感觉阵列的最新结构进展及其取得这些进展的发展。
