Trimarco Valentina, Cimmino Claudia Sara, Santoro Mario, Pagnano Gianpiero, Manzi Maria Virginia, Piglia Anna, Giudice Caterina Anna, De Luca Nicola, Izzo Raffaele
Department of NeuroSciences, Federico II University, Via S. Pansini 5, Naples, Italy.
High Blood Press Cardiovasc Prev. 2012 Sep 1;19(3):117-22. doi: 10.1007/BF03262460.
Current hypertension management guidelines do not recommend drug treatment in subjects with blood pressure (BP) in the high-normal range due to the risk of side effects of the currently available antihypertensive agents that overcomes the possible benefit. Nutraceuticals are free from relevant side effects and could be a valuable strategy for the treatment of these patients.
The objective of this study was to compare the efficacy of two nutraceutical compositions given by the combination of policosanol, red yeast rice extract, berberine, folic acid and coenzyme Q(10) with or without Orthosiphon stamineus in lowering the BP and lipid profile.
Thirty patients with grade 1 essential hypertension and low cardiovascular risk were analysed. At the end of a run-in period, patients were divided into two study arms and assigned to receive the nutraceutical combination with and without Orthosiphon stamineus. All participants underwent 24-hour ambulatory BP monitoring at the end of the run-in period and of the 4-week treatment with each of the two different nutraceutical combinations.
In patients treated with Orthosiphon stamineus a significant reduction of mean 24-hour systolic and diastolic BP levels compared with baseline values was registered and the smoothness index calculated for systolic and diastolic BP showed a more reliable and homogeneous effect on BP over 24 hours. In contrast, nutraceutical treatment without Orthosiphon stamineus was not associated with a significant reduction of BP.
Our results show that the addition of Orthosiphon stamineus to the combination of nutraceuticals confers an antihypertensive effect that allows a surprisingly effective 24-hour BP control in hypertensive patients.
目前的高血压管理指南不建议对血压处于高正常范围的患者进行药物治疗，因为现有抗高血压药物的副作用风险超过了可能带来的益处。营养保健品没有相关副作用，可能是治疗这些患者的有效策略。
本研究的目的是比较两种营养保健品组合物（由聚多卡醇、红曲米提取物、黄连素、叶酸和辅酶Q10组成，含或不含猫须草）在降低血压和改善血脂方面的疗效。
分析了30例1级原发性高血压且心血管风险较低的患者。在导入期结束时，将患者分为两个研究组，分别给予含猫须草和不含猫须草的营养保健品组合。所有参与者在导入期结束时以及使用两种不同营养保健品组合分别进行4周治疗后，均接受24小时动态血压监测。
与基线值相比，接受含猫须草营养保健品治疗的患者24小时平均收缩压和舒张压水平显著降低，收缩压和舒张压的平滑指数显示在24小时内对血压有更可靠和均匀的影响。相比之下，不含猫须草的营养保健品治疗与血压显著降低无关。
我们的结果表明，在营养保健品组合中添加猫须草具有降压作用，能够使高血压患者在24小时内实现惊人有效的血压控制。
