Tabeshpour Jamshid, Imenshahidi Mohsen, Hosseinzadeh Hossein
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2017 May;20(5):557-568. doi: 10.22038/IJBMS.2017.8682.
Metabolic syndrome (MetS), characterized by a cluster of metabolic abnormalities including hypertension, obesity, type 2 diabetes mellitus (T2DM) and dyslipidemia, is a well-known cardiovascular risk factor (CVRF). Cardiovascular disease (CVD) represents a massive healthcare burden worldwide. In recent years, with regard to the adverse effects of synthetic drugs, increasing attention has been paid by researchers to herbal medicines for a variety of disorders such as CVD. A large body of literature supports different pharmacological actions of () and its active component, berberine (BBR), such as antidiabetic, antiobesity, hypotensive and hypolipidemic properties that could be interesting in the management of MetS associated with high CVD risk. Numerous preclinical and studies support all these effects. In this review, we evaluated the most related original articles to discover the role of on various constituents of MetS and CVRF comprising dyslipidemia, obesity, high blood pressure and high blood glucose. This review suggests a potential role of and BBR in the managing of MetS; nevertheless more investigations, especially reliable clinical trials, need to be accomplished to evaluate their effectiveness.
代谢综合征（MetS）以包括高血压、肥胖、2型糖尿病（T2DM）和血脂异常在内的一系列代谢异常为特征，是一种众所周知的心血管危险因素（CVRF）。心血管疾病（CVD）在全球范围内构成了巨大的医疗负担。近年来，鉴于合成药物的不良反应，研究人员越来越关注用于治疗诸如CVD等各种疾病的草药。大量文献支持（）及其活性成分黄连素（BBR）的不同药理作用，如抗糖尿病、抗肥胖、降血压和降血脂特性，这些特性可能对管理与高CVD风险相关的MetS具有重要意义。众多临床前和（此处原文缺失部分内容）研究支持所有这些作用。在本综述中，我们评估了最相关的原始文章，以发现（此处原文缺失部分内容）对MetS和CVRF的各种成分（包括血脂异常、肥胖、高血压和高血糖）的作用。本综述表明（此处原文缺失部分内容）和BBR在管理MetS方面具有潜在作用；然而，需要完成更多研究，尤其是可靠的临床试验，以评估它们的有效性。
