Sun Jia-Yang, Shi Lei, Gao Xu-Dong, Xu Shao-Fa
Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Asian Pac J Cancer Prev. 2012;13(7):3143-7. doi: 10.7314/apjcp.2012.13.7.3143.
Previous studies investigating the association of physical activity with risk of lung cancer reported conflicting results. In order to update and improve available evidence on any link, a meta-analysis was performed.
We searched the PubMed database for prospective cohort studies investigating the relation of physical activity with risk of lung cancer. The pooled relative risk (RR) with its 95% confidence intervals (95%CI) was used to assess the association.
We included 14 prospective studies with a total of 1,644,305 participants, with 14,074 incident lung cancer cases documented during follow-up. Meta-analysis of all 14 studies suggested both high and medium levels of physical activity to be associated with decreased risk of lung cancer compared to the reference group with low level of physical activity (for high level, RR = 0.77, 95%CI 0.73-0.81, P < 0.001; for medium level, RR = 0.87, 95%CI 0.83-0.90, P < 0.001). Subgroup analyses by gender found obvious associations in both men and women. No publication bias was observed.
Our findings suggest that high and medium levels of physical activity have a beneficial effect on lung cancer by reducing the overall risk of tumour development among both men and women.
先前关于体育活动与肺癌风险关联的研究报告结果相互矛盾。为了更新和完善有关任何关联的现有证据，我们进行了一项荟萃分析。
我们在PubMed数据库中检索了调查体育活动与肺癌风险关系的前瞻性队列研究。采用合并相对风险（RR）及其95%置信区间（95%CI）来评估这种关联。
我们纳入了14项前瞻性研究，共有1,644,305名参与者，随访期间记录了14,074例肺癌病例。对所有14项研究的荟萃分析表明，与体育活动水平低的参照组相比，高水平和中等水平的体育活动均与肺癌风险降低相关（高水平：RR = 0.77，95%CI 0.73 - 0.81，P < 0.001；中等水平：RR = 0.87，95%CI 0.83 - 0.90，P < 0.001）。按性别进行的亚组分析在男性和女性中均发现了明显的关联。未观察到发表偏倚。
我们的研究结果表明，高水平和中等水平的体育活动通过降低男性和女性肿瘤发生的总体风险，对肺癌具有有益作用。
