Yadav Naval Kishor, Poudel Bibek, Thanpari C, Chandra Koner Bidhan
Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal.
Asian Pac J Cancer Prev. 2012;13(7):3385-8. doi: 10.7314/apjcp.2012.13.7.3385.
The study was conducted to assess biochemical profiles in premenopausal and postmenopausal women having breast cancer.
A hospital based case control study was carried out at Manipal Teaching Hospital (MTH), Pokhara, Nepal. The analysed variables were age, metabolic profile including total cholesterol, triglycerides, HDL-C, LDL-C, blood sugar, insulin concentration, C-peptide, HbA1c and selenium. Descriptive statistics and testing of hypothesis were used for the analysis using EPI INFO and SPSS 16 software.
In premenopausal women, significant differences were noted for total cholesterol (P value <0.001), triglycerides (P value 0.002), HbA1c level (P value <0.001), insulin concentration (P value 0.030), C-peptide concentration (P value 0.001), and selenium (P value <0.001) between cases and controls. Insignificant results were found for HDL-C (P value 0.749), LDL-C (P value 0.933), blood sugar (P value 0.59) and BMI (P value 0.746). Similarly, significant difference in total cholesterol (P value <0.001), triglycerides (P value 0.001), LDL-C (P value <0.001), HDL-C (P value 0.025), blood sugar (P value <0.001), insulin concentration (P value <0.001), c-peptide concentration (P value <0.001), HbA1c level (P value <0.001) and selenium (P value <0.001) were observed for postmenopausal patients and controls.
Assessing metabolic changes and their management may be important for control of breast cancer and increased survival.
本研究旨在评估患有乳腺癌的绝经前和绝经后女性的生化指标。
在尼泊尔博卡拉的马尼帕尔教学医院（MTH）开展了一项基于医院的病例对照研究。分析的变量包括年龄、代谢指标，如总胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、血糖、胰岛素浓度、C肽、糖化血红蛋白（HbA1c）和硒。使用EPI INFO和SPSS 16软件进行描述性统计和假设检验以进行分析。
在绝经前女性中，病例组和对照组之间的总胆固醇（P值<0.001）、甘油三酯（P值0.002）、HbA1c水平（P值<0.001）、胰岛素浓度（P值0.030）、C肽浓度（P值0.001）和硒（P值<0.001）存在显著差异。高密度脂蛋白胆固醇（P值0.749）、低密度脂蛋白胆固醇（P值0.933）、血糖（P值0.59）和体重指数（P值0.746）的结果无统计学意义。同样，绝经后患者与对照组相比，总胆固醇（P值<0.001）、甘油三酯（P值0.001）、低密度脂蛋白胆固醇（P值<0.001）、高密度脂蛋白胆固醇（P值0.025）、血糖（P值<0.001）、胰岛素浓度（P值<0.001）、C肽浓度（P值<0.001）、HbA1c水平（P值<0.001）和硒（P值<0.001）存在显著差异。
评估代谢变化及其管理对于控制乳腺癌和提高生存率可能很重要。
