LIA135 CNRS.
Eur Cytokine Netw. 2012 Jul-Sep;23(3):101-6. doi: 10.1684/ecn.2012.0312.
Interactions between cytokines and others soluble factors (hormones, antibodies...) can play an important role in the development of thyroid pathogenesis. The purpose of the present study was to examine the possible correlation between serum cytokine concentrations, thyroid hormones (FT4 and TSH) and auto-antibodies (Tg and TPO), and their usefulness in discriminating between different thyroid conditions. In this study, we investigated serum from 115 patients affected with a variety of thyroid conditions (44 Graves' disease, 17 Hashimoto's thyroiditis, 11 atrophic thyroiditis, 28 thyroid nodular goitre and 15 papillary thyroid cancer), and 30 controls. Levels of 17 cytokines in serum samples were measured simultaneously using a multiplexed human cytokine assay. Thyroid hormones and auto-antibodies were measured using ELISA. Our study showed that IL-1β serum concentrations allow the discrimination between atrophic thyroiditis and papillary thyroid cancer groups (p = 0.027).
细胞因子与其他可溶性因子（激素、抗体等）之间的相互作用可能在甲状腺发病机制的发展中起重要作用。本研究的目的是研究血清细胞因子浓度与甲状腺激素（FT4 和 TSH）和自身抗体（Tg 和 TPO）之间的可能相关性，以及它们在区分不同甲状腺疾病中的作用。在这项研究中，我们研究了来自 115 名患有各种甲状腺疾病（44 名 Graves 病、17 名桥本甲状腺炎、11 名萎缩性甲状腺炎、28 名甲状腺结节性甲状腺肿和 15 名甲状腺乳头状癌）和 30 名对照者的血清。使用多重人类细胞因子检测法同时测量血清样本中的 17 种细胞因子的水平。使用 ELISA 法测量甲状腺激素和自身抗体。我们的研究表明，IL-1β 血清浓度可区分萎缩性甲状腺炎和甲状腺乳头状癌组（p=0.027）。
