National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1090 Tusculum Avenue, MS C-14, Cincinnati, OH 45226, USA.
Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Toxicol Lett. 2018 Dec 1;298:112-124. doi: 10.1016/j.toxlet.2018.06.003. Epub 2018 Jun 18.
As the number of nanomaterial workers increase there is need to consider whether biomonitoring of exposure should be used as a routine risk management tool. Currently, no biomonitoring of nanomaterials is mandated by authoritative or regulatory agencies. However, there is a growing knowledge base to support such biomonitoring, but further research is needed as are investigations of priorities for biomonitoring. That research should be focused on validation of biomarkers of exposure and effect. Some biomarkers of effect are generally nonspecific. These biomarkers need further interpretation before they should be used. Overall biomonitoring of nanomaterial workers may be important to supplement risk assessment and risk management efforts.
随着纳米材料从业人员数量的增加，有必要考虑是否应将生物监测作为一种常规的风险管理工具。目前，权威机构或监管机构尚未规定对纳米材料进行生物监测。但是，支持这种生物监测的知识库正在不断增加，但还需要进一步研究，包括对生物监测重点的调查。这项研究应该集中在暴露和影响的生物标志物的验证上。一些影响的生物标志物通常是非特异性的。在将这些生物标志物用于实际之前，还需要进一步解释。对纳米材料工人进行总体生物监测可能对补充风险评估和管理工作很重要。
