Division of Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri 63110, USA.
Obstet Gynecol. 2012 Oct;120(4):783-90. doi: 10.1097/AOG.0b013e318269c8bb.
To estimate trends in contraceptive use, especially long-acting reversible contraceptives (LARCs) and condoms, among human immunodeficiency virus (HIV)-seropositive and HIV-seronegative women.
Human immunodeficiency virus-seropositive and HIV-seronegative women in a multicenter longitudinal cohort were interviewed semiannually between 1998 and 2010 about sexual behaviors and contraceptive use. Trends in contraceptive use by women aged 18-45 years who were at risk for unintended pregnancy but not trying to conceive were analyzed using generalized estimating equations.
Condoms were the dominant form of contraception for HIV-seropositive women and showed little change across time. Less than 15% of these women used no contraception. Between 1998 and 2010, LARC use increased among HIV-seronegative women from 4.8% (6 of 126) to 13.5% (19 of 141, P=.02), but not significantly among seropositive women (0.9% [4 of 438] to 2.8% [6 of 213], P=.09). Use of highly effective contraceptives, including pills, patches, rings, injectable progestin, implants, and intrauterine devices, ranged from 15.2% (53 of 348) in 1998 to 17.4% (37 of 213) in 2010 (P=.55). Human immunodeficiency virus-seronegative but not HIV-seropositive LARC users were less likely than nonusers to use condoms consistently (hazard ratio 0.51, 95% confidence interval [CI] 0.32-0.81, P=.004 for seronegative women; hazard ratio 1.09, 95% CI 0.96-1.23 for seropositive women).
Although most HIV-seropositive women use contraception, they rely primarily on condoms and have not experienced the increase in LARC use seen among seronegative women. Strategies to improve simultaneous use of condoms and LARC are needed to minimize risk of unintended pregnancy as well as HIV transmission and acquisition of sexually transmitted infections.
II.
评估艾滋病毒(HIV)阳性和 HIV 阴性妇女中避孕措施的使用趋势,尤其是长效可逆避孕措施(LARC)和避孕套的使用趋势。
1998 年至 2010 年间,对来自多中心纵向队列的 HIV 阳性和 HIV 阴性的处于意外妊娠风险但未尝试怀孕的 18-45 岁妇女进行半年度访谈,了解性行为和避孕措施的使用情况。使用广义估计方程分析了有意外妊娠风险但未尝试怀孕的 18-45 岁妇女避孕措施的使用趋势。
对于 HIV 阳性妇女,避孕套是主要的避孕方式,且在整个研究期间变化不大。这些妇女中不到 15%的人不使用任何避孕措施。1998 年至 2010 年间,HIV 阴性妇女中 LARC 的使用率从 4.8%(126 例中的 6 例)上升至 13.5%(141 例中的 19 例,P=0.02),而 HIV 阳性妇女中的 LARC 使用率无显著变化(0.9%(438 例中的 4 例)至 2.8%(213 例中的 6 例,P=0.09)。包括避孕药、贴片、环、注射用孕激素、植入物和宫内节育器在内的高效避孕措施的使用率从 1998 年的 15.2%(348 例中的 53 例)上升至 2010 年的 17.4%(213 例中的 37 例,P=0.55)。与未使用者相比,HIV 阴性的 LARC 使用者持续使用避孕套的可能性较低(HR 0.51,95%CI 0.32-0.81,P=0.004;对于 HIV 阳性妇女,HR 1.09,95%CI 0.96-1.23)。
尽管大多数 HIV 阳性妇女使用避孕措施,但她们主要依赖避孕套,并且 LARC 的使用并未像 HIV 阴性妇女那样增加。需要采取策略来改善避孕套和 LARC 的同时使用,以最大限度地降低意外怀孕、HIV 传播和性传播感染的风险。
II。