Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.
Int J Oral Sci. 2012 Sep;4(3):135-40. doi: 10.1038/ijos.2012.54. Epub 2012 Sep 21.
Alkali production by oral bacteria is believed to have a major impact on oral microbial ecology and to be inhibitory to the initiation and progression of dental caries. A substantial body of evidence is beginning to accumulate that indicates the modulation of the alkalinogenic potential of dental biofilms may be a promising strategy for caries control. This brief review highlights recent progress toward understanding molecular genetic and physiologic aspects of important alkali-generating pathways in oral bacteria, and the role of alkali production in the ecology of dental biofilms in health and disease.
口腔细菌产生的碱被认为对口腔微生物生态有重大影响，并能抑制龋齿的发生和发展。越来越多的证据表明，调节牙菌斑的产碱潜能可能是控制龋齿的一种有前途的策略。本文简要综述了近年来在理解口腔细菌中重要产碱途径的分子遗传和生理方面的进展，以及在健康和疾病状态下，产碱在牙菌斑生态中的作用。
