Department of Biological and Agricultural Engineering, Louisiana State University and LSU AgCenter, Louisiana, USA.
J Biomed Mater Res B Appl Biomater. 2013 Jan;101(1):187-99. doi: 10.1002/jbm.b.32817. Epub 2012 Sep 21.
In the past decade, substantial strides have been taken toward the use of human adipose-derived stromal/stem cells (hASC) in the regeneration of bone. Since the discovery of the hASC osteogenic potential, many models have combined hASC with biodegradable scaffold materials. In general, rats and immunodeficient (nude) mice models for nonweight bearing bone formation have led the way to assess hASC osteogenic potential in vivo. The goal of this review is to present an overview of the recent literature describing hASC osteogenesis in conjunction with three-dimensional scaffolds for bone regeneration.
在过去的十年中，人们在利用人脂肪来源的基质/干细胞（hASC）促进骨再生方面取得了重大进展。自发现 hASC 的成骨潜能以来，许多模型都将 hASC 与可生物降解的支架材料结合使用。通常，用于非承重骨形成的大鼠和免疫缺陷（裸）鼠模型为评估 hASC 的体内成骨潜能开辟了道路。本文的目的是综述近年来关于 hASC 与三维支架结合用于骨再生的成骨作用的文献。
