一株从西非鸡中分离的新型新城疫病毒株的全基因组序列。
Complete genome sequence of a novel Newcastle disease virus strain isolated from a chicken in West Africa.
机构信息
Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
出版信息
J Virol. 2012 Oct;86(20):11394-5. doi: 10.1128/JVI.01922-12.
Abstract
The complete genome sequence of an African Newcastle disease virus (NDV) strain isolated from a chicken in Togo in 2009 was determined. The genome is 15,198 nucleotides (nt) in length and is classified in genotype VII in the class II cluster. Compared to common vaccine strains, the African strain contains a previously described 6-nt insert in the downstream untranslated region of the N gene and a novel 6-nt insert in the HN-L intergenic region. Genome length differences are a marker of the natural history of NDV. This is the first description of a class II NDV strain with a genome of 15,198 nt and a 6-nt insert in the HN-L intergenic region. Sequence divergence relative to vaccine strains was substantial, likely contributes to outbreaks, and illustrates the continued evolution of new NDV strains in West Africa.
摘要
2009 年，从多哥的一只鸡中分离出一株非洲新城疫病毒（NDV），测定了其完整基因组序列。基因组全长 15198 个核苷酸（nt），属于二类群中的 VII 基因型。与常见疫苗株相比，非洲株在 N 基因的下游非翻译区有一个之前描述过的 6-nt 插入，在 HN-L 基因间区有一个新的 6-nt 插入。基因组长度差异是 NDV 自然史的一个标志。这是首次描述具有 15198nt 基因组和 HN-L 基因间区 6-nt 插入的 II 类 NDV 株。与疫苗株相比，序列差异很大，可能导致了暴发，并说明了新的 NDV 株在西非的持续进化。
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